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12 (0,555s) •

Project

Changes in kinetochore composition and structure associated with holocentric chromosome formation (GA20-25440S)

The centromere and kinetochore are essential for proper chromosome segregation is of great importance. Most research into centromeres and kinetochores has so far been kinetochores appeared to be relatively conserved even am...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2023
    • •
  • 8 008 tis. Kč
    • •
  • 8 008 tis. Kč
    • •
  • GA ČR
Project

Composition of plant kinetochores and its evolutionary plasticity in the context of centromere organization (GA25-15809S)

The kinetochore is a complex multiprotein structure that connects chromosomes. While the composition, structure, and function of the kinetochore have been studied in great detail in fungal and animal models, our knowledge of kin...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2027
    • •
  • 10 332 tis. Kč
    • •
  • 10 332 tis. Kč
    • •
  • GA ČR
Project

Evolution of genome size - a new role for the centromere drive (GA20-15989S)

Maintaining the size ratio of chromosomes (“luggage”) and their kinetochores (“handles”) should mean that the kinetochore size divergence caused by centromere drive of kinetochore and chromosome sizes across species and wit...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2020 - 2023
    • •
  • 8 866 tis. Kč
    • •
  • 8 866 tis. Kč
    • •
  • GA ČR
Project

When 1+1≠2 Conundrum of non-Mendelian inheritance of parental chromosomes in plant hybrids (GA24-10010S)

is associated with allele-specific silencing of kinetochore genes from one parent before the kinetochore is assembled in plant hybrids and how compatible the individual kinetochore A. lyrata crosses using mutants of ki...

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2026
    • •
  • 7 707 tis. Kč
    • •
  • 7 707 tis. Kč
    • •
  • GA ČR
Project

Universality of mitotic spindle assembly architecture of the kinetochore and centrosome in the bi-nucleated parasitic protist Giardia intestinalis (GA20-06498S)

– kinetochores and centrosomes. The objective is to gain an insight into nucleation, and the intimate microtubule-kinetochore interaction in Giardia. We also aim to characterize proximal interactomes of some of the so-far identifie...

Parasitology

  • 2020 - 2023
    • •
  • 7 089 tis. Kč
    • •
  • 7 089 tis. Kč
    • •
  • GA ČR
Project

What do the most abundant oceanic protistan proteins actually do? (GX23-06479X)

as kinetochores, which remain unstudied in several ecologically and evolutionarily important...

Cell biology

  • 2023 - 2027
    • •
  • 42 471 tis. Kč
    • •
  • 42 471 tis. Kč
    • •
  • GA ČR
Project

New unexpected role for check-point kinase 1 Regulation of spindle dynamics and spindle-assembly checkpoint during oocyte meiotic maturation (GC301/09/J036)

in Chk1 KO oocytes. Association of Chk1 with spindle and centromeres/kinetochores of Chk1 with kinetochores and centrosomes. The advanced live-cell imaging experiments......

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 2 647 tis. Kč
    • •
  • 2 647 tis. Kč
    • •
  • GA ČR
Project

Microtubule organization in plant cells - development and application of in vitro assays for study of nucleation activity of isolated nuclei and chromosomes (GA204/99/D092)

in kinetochore region of isolated chromosomes as well as in interphase nuclei and in addition...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 1 075 tis. Kč
    • •
  • 481 tis. Kč
    • •
  • GA ČR
Project

Maintenance of chromosome integrity in Giardia intestinalis, a unicellular bi-nucleated eukaryote with minimalistic genome (GAP305/12/1248)

Eukaryotic cells possess unique chromosomal structures and mechanisms maintaining the stability of genetic information such as centromeres, telomeres and cell cycle checkpoints. Giardia intestinalis represents a novel model organism for studies of su...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 425 tis. Kč
    • •
  • 5 425 tis. Kč
    • •
  • GA ČR
Project

Adaptation of control mechanisms of chromosome segregation to dramatic changes during transition from oocytes to early embryos. (GA17-20405S)

to a ratio between cell size and kinetochore numbers. The aim of proposed study...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2017 - 2021
    • •
  • 7 671 tis. Kč
    • •
  • 7 230 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 12