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992 (0,25s) •

Project

Driver mutations in cancer genome of Nothobranchius furzeri from tumor biology to concept of experimental model of spontaneous carcinogenesis (GA19-20873S)

species that recapitulate standard vertebrate ageing and display spontaneous age that there is considerable number of mutations in genes related to the processes involved in malignant transformation. The aim of the project is to de...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 311 tis. Kč
    • •
  • 7 774 tis. Kč
    • •
  • GA ČR
Project

Genes influencing limb patterning morphology and functional genomics of hypodactyly and polydactyly-luxate mutations in the Norway rat (GA304/06/0116)

Spontaneous mutations in model organisms were proven as important tools anddevelopmental analysis of mutations causing limb malformations - hypodactyly (hd for the role of the studied mutations in limb patterning i...

EA - Morfologické obory a cytologie

  • 2006 - 2008
    • •
  • 4 826 tis. Kč
    • •
  • 4 772 tis. Kč
    • •
  • GA ČR
Project

Population,clinical and molecular genetic study of mutations linked to thrombophilia for an early prevention and treatment (NM6250)

Determinantion of the population distribution of known mutations in genes for proteinC,protein S,Faktors II,V,VIII,thrombomodulin and homocystinemia for improvement of mutations in these genes in "thrombophilic"exons in children and...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2000 - 2002
    • •
  • 1 863 tis. Kč
    • •
  • 1 863 tis. Kč
    • •
  • MZ
Project

Identification of molecular and functional basis of pathophysiological phenotypes in the spontaneously hypertensive rat (LH12061)

variants of mutated genes will be tested in metabolic and hemodynamic parameters...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 4 500 tis. Kč
    • •
  • 3 750 tis. Kč
    • •
  • MŠMT
Project

Control of hotspots of meiotic double-strand DNA breaks in Rattus norvegicus (GA16-06548S)

yet not all mice heterozygous for certain Prdm9 mutations display sex-specific in Prdm9 mutations or in genetic background. Sterile human patients with heterozygous PRDM9 mutations were identified; however, these mutat...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 8 727 tis. Kč
    • •
  • 8 274 tis. Kč
    • •
  • GA ČR
Project

The identification and the characterization of the leukemia-inhibitory factor gene mutations in the population of women with idiopathic infertility (GA301/02/1232)

spontaneously. LIF gene mutations will be identified using the temperature-gradient gel failure. Our experiments will focus on mutations that can result in the decreased LIF......

FK - Gynekologie a porodnictví

  • 2002 - 2004
    • •
  • 1 700 tis. Kč
    • •
  • 1 700 tis. Kč
    • •
  • GA ČR
Project

Mutated nucleophosmin as a potential target for immunotherapy of acute myelogenous leukemia (NV16-30268A)

Nucleophosmin (NPM) C-terminal mutations are detected in about 30% of patients with appropriate HLA alleles (about 85% of population) are able to raise spontaneous immune response against mutated NPM which can prevent AML d...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 11 230 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
Project

Analysis of the effects of Cd36 (fat) transgene in spontaneously hypertensive rats on clustering of cardiovascular risk factors (GA301/00/1636)

Numerous studies in humans and animal models have suggested that alterations in fatty acid and lipid metabolism can contribute to the pathogenesis of insulin resistance and hypertension. It has been demonstrated that: 1) the SHR carriers mutation...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 2 780 tis. Kč
    • •
  • 1 919 tis. Kč
    • •
  • GA ČR
Project

Functions and molecular interactions of DOA protein kinase in signal transduction during Drosophila development. (GA304/02/0342)

. The mutations in Doa gene are responsible for complex phenotype with malformed and blind and appendage morphogenesis. Doa alleles are also dominant suppressors of mutations induced to a chromosomal location incriminated in a high ...

EA - Morfologické obory a cytologie

  • 2002 - 2004
    • •
  • 3 804 tis. Kč
    • •
  • 2 945 tis. Kč
    • •
  • GA ČR
Project

The improvement of an early detection of spontaneous heating of coal and control its advacement of licvidation focused on indication gases (AACBU29-03)

Confirmation and verification of the nature and artificial factors distort early detection of spontaneous heating of coal and application of the results to today used methods. Elaboration of the new versions of diagnostic software for an ear...

DH - Báňský průmysl včetně těžby a zpracování uhlí

  • 2003 - 2005
    • •
  • 7 250 tis. Kč
    • •
  • 7 250 tis. Kč
    • •
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