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11 391 (0,082s) •

Project

Tumor stress-induced proteins as target structures for cytotoxic cells (IAA5020403)

of stress-induced proteins at tumor cell surface. In the current proposal we suggestto,we would like to investigate details of the chemical structures involved in these interactions. These chemical structures of carbohydra...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2008
    • •
  • 4 917 tis. Kč
    • •
  • 4 917 tis. Kč
    • •
  • AV ČR
Project

High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. (2B06077)

DNA in nucleus is wrapped into nucleo-protein structure known as chromatin. Any or gene repair factors. Three independet laboratories with expertise in leukemia/tumor genome high throughput analysis of chromatin structure a...

EB - Genetika a molekulární biologie

  • 2006 - 2011
    • •
  • 53 217 tis. Kč
    • •
  • 47 631 tis. Kč
    • •
  • MŠMT
Project

Branched and hyperbranched polymer carriers of drugs for local therapy (IAA400500806)

to the solid tumor. Increased molecular weight, structure of polymer carrier and shape of polymer chain should provide effective accumulation of system in tumors dueto the EPR delivery system intended for application in si...

CD - Makromolekulární chemie

  • 2008 - 2011
    • •
  • 6 448 tis. Kč
    • •
  • 6 448 tis. Kč
    • •
  • AV ČR
Project

The role of p53 DNA structure-selective binding in brain cancer (GAP301/10/2370)

Brain tumors are highly invasive types of cancer. The inactivation of specific genes together with point mutation in tumor suppressor Tp53 gene portends poor that mainly contributes to tumor aggressiveness by regulation of ...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 757 tis. Kč
    • •
  • 1 757 tis. Kč
    • •
  • GA ČR
Project

The development of ruthenium antitumor compounds (OC D8.50)

at present in chemotherapy of tumors, the number of tumors sensitive to these cytostatics was tested using model tumors, the ruthenium complexes yielded promising results. It has tumors resistant to cisplatin and ...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 6 030 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • MŠMT
Project

Structural immunology of NK cell recognition from tumor evasion to its eradication (GA25-18490S)

Structural immunology of NK cell recognition is a hot spot of research on the borderline of structural biology, immunology, and experimental immunotherapy. Understanding the recognition processes delineating tumor evasion f...

Microbiology

  • 2025 - 2027
    • •
  • 9 336 tis. Kč
    • •
  • 9 336 tis. Kč
    • •
  • GA ČR
Project

Topographic and functional characterization of telomeres in various tumor cell lines determined in situ and in vivo (GP204/05/P090)

All human tumors as well as immortalized cell lines, which have been analyzed. The ribonucleoprotein enzyme, known as telomerase, elongates telomeres in most tumors (85 to 90-negative tumors, which are provided with alterna...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 175 tis. Kč
    • •
  • 1 175 tis. Kč
    • •
  • GA ČR
Project

The diagnostic and therapeutic potential of fibroblast activation protein (FAP) in human astrocytic tumors (NT12237)

Malignant gliomas represent tumors with dismal prognosis. Previous work enzymatic activity in human astrocytic tumors. This enzymatic activity is a common and/or structure homologues” (DASH). These include among others fibr...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 7 268 tis. Kč
    • •
  • 7 268 tis. Kč
    • •
  • MZ
Project

*Development of kit for testing molecular effects of anti-tumor drugs on chromatin structure (FR-TI2/509)

*Malignances represent important socio-economic problem caused at molecular levels by uncontrolled cell proliferation and block of cell differentiation. Biological anti-tumor therapy is aimed to interfere with mechanisms that are behind thes...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 20 016 tis. Kč
    • •
  • 14 812 tis. Kč
    • •
  • MPO
Project

Global methylation profiles and comprehensive analysis of gene fusions as a basis for therapeutic planning in pediatric oncology (NV19-03-00562)

of the tumor. In addition to changes in the coding regions of DNA (tumor exome methylation or structural rearrangements leading to the formation of fusion genes. Number of these methylation changes and fusions strongly inf...

Oncology

  • 2019 - 2023
    • •
  • 15 965 tis. Kč
    • •
  • 15 904 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 11 391