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1 174 (0,157s) •

Project

Bioorthogonal time-controlled intramitochondrial elimination (GF20-30494L)

Bioorthogonal bond-cleavage is an emerging topic in the field of in vivo chemistry. However, while the current major focus is to achieve fast and complete. To address this, we will design and synthesize new bioorthogonal to...

Organic chemistry

  • 2020 - 2022
    • •
  • 8 156 tis. Kč
    • •
  • 7 933 tis. Kč
    • •
  • GA ČR
Project

Construction of synthetic scaffolds enabling subcellular organelle-specific release chemistry (GA19-13811S)

bioorthogonal reactions are known mainly as efficient chemical transformations leading to formation of covalent bonds. It has been only recently when the concept of bioorthogonal reactions was extended to something what is known as...

Organic chemistry

  • 2019 - 2021
    • •
  • 7 481 tis. Kč
    • •
  • 7 082 tis. Kč
    • •
  • GA ČR
Project

Photochemical Catch and Release Strategy Towards Novel Molecular Switches and Bioorthogonal Reactions (GA22-20319S)

Bioorthogonal reactions and photoswitches, experiencing rapid growth in the last decades, use click reactions for covalent attachment of an actuating molecule to another (bio)molecule and clip processes for selective cleavage of chemical bon...

Organic chemistry

  • 2022 - 2024
    • •
  • 8 075 tis. Kč
    • •
  • 7 092 tis. Kč
    • •
  • GA ČR
Project

Bioorthogonal reactions of 1-alkyl-1,2,4-triazinium salts (GA24-10829S)

of biological systems. These reactions, also known as bioorthogonal, have found applications in many areas that extend far beyond organic chemistry laboratories. The development bioorthogonal reagents. The project includes...

Organic chemistry

  • 2024 - 2026
    • •
  • 8 755 tis. Kč
    • •
  • 8 232 tis. Kč
    • •
  • GA ČR
Project

Hybrid biocompatible nanocatalysts for extracellular bioorthogonal activation of prodrugs (GM23-04740M)

modalities. Therefore, we plan to benefit from a concept of bioorthogonal chemistry efficiency of bioorthogonal pairs in murine model. The proposed project will open up new......

Biochemistry and molecular biology

  • 2023 - 2027
    • •
  • 23 843 tis. Kč
    • •
  • 23 843 tis. Kč
    • •
  • GA ČR
Project

Artificial epigenetics Development of a eukaryotic bioorthogonal transcription system for gene expression manipulation in the cell. (GA17-03419S)

for bioorthogonal reactions and gene expression manipulation in eukaryotic systems....

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 537 tis. Kč
    • •
  • 9 072 tis. Kč
    • •
  • GA ČR
Project

Modifications and bioorthogonal reactions in the major groove of DNA for regulation of protein binding and gene expression (GA14-04289S)

will be systematically studied. Transformations of these attached groups by bioorthogonal reactions...

CE - Biochemie

  • 2014 - 2016
    • •
  • 9 994 tis. Kč
    • •
  • 9 994 tis. Kč
    • •
  • GA ČR
Project

Development of new bioorthogonal reactions (GJ15-06020Y)

Current methodologies for labeling of biomolecules have drawbacks such as: bad synthetic accessibility of starting materials, low stability of the reagents under physiological conditions, need for catalysis or formation of isomeric products. New conc...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 5 716 tis. Kč
    • •
  • 5 716 tis. Kč
    • •
  • GA ČR
Project

Representation of Czech analytical chemistry in European Association for Chemical and Molecular Sciences (EuCheMS) and in European Society for Electroanalytical Chemistry (ESEAC). (LA10034)

The aim of the project is to support activities of prof. J. Barek in Division od Analytical Chemistry of the European Association for Chemical and Molecular Sciences and in European Society for Electroanalytical Chemistry.......

CB - Analytická chemie, separace

  • 2010 - 2012
    • •
  • 210 tis. Kč
    • •
  • 210 tis. Kč
    • •
  • MŠMT
Project

Chemistry at the German University of Prague 1882?1945 in comparison with the universities of Leipzig and Vienna (IAA801040703)

of the intended project ? Chemistry and Medicine Chemistry. The important Departments of Chemistry at the German University of Prague (1882?1945), especially in an international in the History of Sciences. Thus, in order t...

AB - Dějiny

  • 2007 - 2009
    • •
  • 1 525 tis. Kč
    • •
  • 1 525 tis. Kč
    • •
  • AV ČR
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