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8 512 (0,093s) •

Project

Radionuclide precursors and radiopharmaceuticals for targeted radionuclide imaging and therapy (OE08018)

The proposed project aims to promote development and production of of modern diagnostic and therapeutic radionuclides and radiopharmaceuticals i the Czech Republic.......

FR - Farmakologie a lékárnická chemie

  • 2008 - 2011
    • •
  • 21 000 tis. Kč
    • •
  • 10 500 tis. Kč
    • •
  • MŠMT
Project

Development of novel antidotal treatment against organophosphorus pesticides (ME09086)

and in vitro evaluation of novel or formerly prepared compounds will be used. Such reactivator will be further tested in vivo and might become a candidate for the preclinical trials against OPP.......

FR - Farmakologie a lékárnická chemie

  • 2009 - 2012
    • •
  • 1 692 tis. Kč
    • •
  • 1 692 tis. Kč
    • •
  • MŠMT
Project

Human mesenchymal stromal cells for therapeutic purposes. Preclinical and pharmacological testing and approval of the cellular product for clinical use. (NT13531)

performed to proof the concept, to characterize the cells and to test safety of the cellular product in vitro and in vivo. Patented method of cultivation will be transferred to conditions of good manufacturing practice (GMP). P...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 9 234 tis. Kč
    • •
  • 9 234 tis. Kč
    • •
  • MZ
Project

*Development of new technologies of preclinical testing of drugs. (FF-P2/025)

*The main aim of the project "Development of new technologies of pre-clinical testing of medical drugs" is development and introduction of new methods of long-term studies on higher mammal models such as dogs and monkeys.......

EG - Zoologie

  • 2003 - 2005
    • •
  • 11 297 tis. Kč
    • •
  • 2 199 tis. Kč
    • •
  • MPO
Project

The design and synthesis of novel ergopeptides with migraine-prophylactic properties (1P04OE159)

development of novel pharmaceutical preparations, migraine prevention, preclinical tests, novel ergopeptines...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2006
    • •
  • 9 600 tis. Kč
    • •
  • 4 800 tis. Kč
    • •
  • MŠMT
Project

Centrally acting antidotes for the treatment of organophosphorus poisoning (NV17-32801A)

of series of in vitro and in vivo tests compounds will be evaluated and described. The best candidate of the preclinical development and with practical potential......

FR - Farmakologie a lékárnická chemie

  • 2017 - 2020
    • •
  • 8 990 tis. Kč
    • •
  • 8 990 tis. Kč
    • •
  • MZ
Project

Preclinical development of new highly selective CK1 inhibitors for the treatment of selected oncological diseases (FW06010481)

diseases. The technology is currently in the preclinical phase of CLL research). Project activities: - Identification of lead candidates for advanced preclinical experiments - Initiation of GLP preclinical experiments - Co...

Pharmacology and pharmacy

  • 2023 - 2025
    • •
  • 20 862 tis. Kč
    • •
  • 14 275 tis. Kč
    • •
  • TA ČR
Project

Study and development of new epigenetic modulators intended for cancer treatment (LUAUS23247)

Our group recently developed a platform for preclinical testing of HDACis, which was used in collaboration with partners in the USA for pilot testing and, above all, to use this platform to test new HDAC6-specific ...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2023 - 2026
    • •
  • 6 989 tis. Kč
    • •
  • 6 989 tis. Kč
    • •
  • MŠMT
Project

A new material for therapeutic embolization laboratory tests, animal experiment, preclinical study. (IZ946)

9F - 9

  • 1992 - 1995
    • •
  • 100 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MZ
Project

Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation (GA20-12047S)

will be subjected to thorough preclinical in vivo testing in order to evaluate and verifyIn this project, we would like to follow-up the proof-of-concept project no. 16-08554S, focused on the dually acting tacrine derivatives, in t...

Medicinal chemistry

  • 2020 - 2022
    • •
  • 14 855 tis. Kč
    • •
  • 14 689 tis. Kč
    • •
  • GA ČR
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