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513 (0,114s) •

Project

PRODUCTION OF RECOMBINANT IMMUNOCYTOKINES FOR TUMOR IMMUNOTHERAPY (IAA500200712)

Effective cancer theraphy through immunomodulation is one of the most important long-term goal of imunology. Although IL-2 and IL-12, one of the most promising is to produce and test IL-2- and IL-12

EC - Imunologie

  • 2007 - 2011
    • •
  • 4 725 tis. Kč
    • •
  • 4 725 tis. Kč
    • •
  • AV ČR
Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

projectby insertion of IL-2 and GM-CSF genes into HPV16+ tumour cells The research will also be focused on the therapeutic effects of IL-2, IL-12 and GM-CSF cytokines......

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

IL-35 a novel cytokine in systemic rheumatic diseases (NT12440)

IL-35 is a novel cytokine of IL-12 family with unknown functions in human diseases. Since our discovery of increased IL-35 in synovial fluid, its association) is a newfinding; our aims are to analyze serum levels o...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2011 - 2014
    • •
  • 7 701 tis. Kč
    • •
  • 7 701 tis. Kč
    • •
  • MZ
Project

Mechanisms underlying cyclophosphamide-induced accumulation of myeloid derived suppressor cells (GPP301/11/P220)

cyclophosphamide chemotherapy (role of proinflammatory cytokines such as VEGF, IL-1, and GM-CSF) and to identify antagonists that could be used for concurrent immunotherapy (IL-12, anti-VEGF......

FD - Onkologie a hematologie

  • 2011 - 2013
    • •
  • 1 800 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • GA ČR
Project

Potentiation of anti-tumor immunity with cytokine immnocomplexes during treatment with polymer-bound drugs (GP301/07/P192)

the treatment. The immunomodulation will be provided in the form of IL-2/anti-IL-2 mAb immunocomplexes, which were shown to possess high activity in vivo [12], either alone or together with IL-12. Such co...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 1 464 tis. Kč
    • •
  • 1 464 tis. Kč
    • •
  • GA ČR
Project

Immune mechanisms of action of antiviral acyclic nucleoside phosphonates (ANP) (GA305/00/0048)

of interleukins (e.g. IL-2m IL-6, IL-12, IL-16, IL-18, etc.), which have been of TNF-alpha and IL-10 production. The major aim of this project is complex......

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 844 tis. Kč
    • •
  • 2 844 tis. Kč
    • •
  • GA ČR
Project

Imunization against Tumors Characterized by Different Escape Mechanisms (NC7552)

IL-12, GM-CSF, Flt3L, IL-2 or soluble TGF-beta type II receptor. Immunization...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 12 151 tis. Kč
    • •
  • 11 594 tis. Kč
    • •
  • MZ
Project

Effect of probiotic lactobacilli on the development of allergy in an experimental model of human disease (IAA500200710)

lymphocytes, analyzed by the production of regulatory (TGF-beta1, IL-10), pro-inflammatory (IL-12, IFN-gamma, IL-18) and allergic (IL-5) cytokines and expression of innate......

EC - Imunologie

  • 2007 - 2011
    • •
  • 3 030 tis. Kč
    • •
  • 3 030 tis. Kč
    • •
  • AV ČR
Project

Acute and chronic colitis induced by DSS and transfer by CD4+CD45RBhigh T lymphocytes in immunodeficient (SCID) mice the role of microflora, using probiotics. (GA303/04/0849)

will be determine surface markers of macrophages (CD11b) and natural killers, receptors of IL-10, IL-12 and IL-18 and also the production of these cytokines will be determined......

ED - Fyziologie

  • 2004 - 2006
    • •
  • 2 228 tis. Kč
    • •
  • 2 228 tis. Kč
    • •
  • GA ČR
Project

Development of immune responses to birch pollen allergen after colonization of mucosal surfaces with recombinant lactobacilli expressing this allergen (GA303/05/2249)

the immunomodulatory potential of lactobacilli, attributed to their Thl responses producing IL-12 and IFN-y, in relation to birch pollen allergen involving activation of Th2 cells (IL-4, IL-5) and specific IgE, we...

EC - Imunologie

  • 2005 - 2007
    • •
  • 2 477 tis. Kč
    • •
  • 2 477 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 513