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13 406 (0,248s) •

Project

Electrochemical and analytical aspects of the transport of addictive and psychotropic drugs across the model biological barriers (GA20-07350S)

The project will be focused on the kinetics and thermodynamics of transfer of selected antipsychotic, antidepressant and analgesic drugs in their ionic forms across the polarized liquid-liquid interfaces and liquid membranes, as model bi...

Organic chemistry

  • 2020 - 2023
    • •
  • 9 384 tis. Kč
    • •
  • 9 384 tis. Kč
    • •
  • GA ČR
Project

New drug delivery systems to cross biological barriers based on the unique properties of carboranes (GA18-27648S)

their penetration across biological membranes/barriers and their pharmacological properties. Recently we have observed some of them to cross readily and actively in vitro models of gastrointestinal and/or blood brain ...

Pharmacology and pharmacy

  • 2018 - 2021
    • •
  • 8 328 tis. Kč
    • •
  • 7 829 tis. Kč
    • •
  • GA ČR
Project

Boreal land snail diversification promoted by isolation through space and time (GA20-18827S)

barriers on biological isolation and allopatric speciation can still be observed. We will then use this data to document the role of isolation barriers over deeper macroevolutionary time scales by predicting range limits a...

Ecology

  • 2020 - 2022
    • •
  • 7 024 tis. Kč
    • •
  • 7 024 tis. Kč
    • •
  • GA ČR
Project

Advanced Glycomimetics for the Treatment of Age-Related Neurodegenerative Disorders A Complex Biological Exploration (GF25-15587K)

and neurodegeneration in advanced biological models, which include static and dynamic BBB models, evaluation of Tau phosphorylation inhibition in a human AD model using cerebral organoids through rigorous biol...

Pharmacology and pharmacy

  • 2025 - 2028
    • •
  • 12 860 tis. Kč
    • •
  • 12 860 tis. Kč
    • •
  • GA ČR
Project

NANOCOMPOSITES-Materials based on polymer nanocomposites with high barrier effect*** (ONSYNPO200301)

Development of technology of production of polymer-clay nanocomposites with high resistance against penetration of toxic and biological compounds.***......

CD - Makromolekulární chemie

  • 2003 - 2005
    • •
  • 5 000 tis. Kč
    • •
  • 5 000 tis. Kč
    • •
  • MO
Project

Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3 (GC301/08/J053)

Desquamation of the epidermis, a process that is dependent on serine proteases and their inhibitors, is fundamental for maintaining the barrier function of the skin-Syndrome characterized by disruption of the skin barrier. Currently...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 4 482 tis. Kč
    • •
  • 4 482 tis. Kč
    • •
  • GA ČR
Project

Nanobiotechnologies and biosensor for biointeraction studies - openning up the modern technology to researchers in biology (EE2.3.09.0167)

-based methods for biomolecular interactions to researchers from biological oriented to the problems from the life science area. In this way, the barrier existing between biologically educated experts and the complicated ph...

AM - Pedagogika a školství

  • 2009 - 2012
    • •
  • 4 395 tis. Kč
    • •
  • 4 395 tis. Kč
    • •
  • MŠMT
Project

Toward 3D modeling of brain barriers (8J21DE001)

and mechanical properties of the B-CSF barrier in the 3D system. 4. To design an in-vitro BBB 3D model for barrier permeability alteration studies 5. To apply. To expand the 3D model assemblies toward designing ...

Clinical neurology

  • 2021 - 2022
    • •
  • 278 tis. Kč
    • •
  • 278 tis. Kč
    • •
  • MŠMT
Project

Corneocyte lipid envelope lipid-protein binding mechanisms and barrier rescue in ichthyosis models (GA24-10736S)

will be synthesized and used for a development of an in vitro model to study the CLE formation via the attachment of these lipids to model aminoacids (including anchored), peptides, proteins and ex-vivo cultivated human skin. Usin...

Biophysics

  • 2024 - 2026
    • •
  • 8 301 tis. Kč
    • •
  • 8 301 tis. Kč
    • •
  • GA ČR
Project

Dinamics of absorbed atoms and cration of nanostructures. (ME 655)

Project intends to formulate a microscopic model describing accurate energetic barriers of separation and jumps of atom....

BF - Elementární částice a fyzika vysokých energií

  • 2003 - 2005
    • •
  • 973 tis. Kč
    • •
  • 563 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 13 406