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12 (0,08s) •

Project

Pharmacological mimicry of microbial metabolites in the modulation of intestinal health (GA22-00355S)

. Pregnane X receptor (PXR) is a common molecular denominator of IBD and CRC onset and progress. The appropriate endogenous activation of the PXR is determinative for the intestinal health, whereas insufficient or over-activation of...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 11 892 tis. Kč
    • •
  • 11 892 tis. Kč
    • •
  • GA ČR
Project

Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases (GA22-05167S)

Xenobiotic receptors, Pregnane X (PXR) and Constitutive androstane (CAR) receptors are important regulators of detoxification. In the past, agonists of PXR CAR/PXR ligands regulate bile acid and cholesterol metabolism in hu...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 12 904 tis. Kč
    • •
  • 12 856 tis. Kč
    • •
  • GA ČR
Project

Study of potential interaction of constituents of non-alcoholic beverages with signaling pathways involved in drug metabolism and carcinogenesis (GAP503/10/0579)

xenoreceptors, i.e. aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR beverages on AhR and PXR activities. Gene reporter assays, RT-PCR, immunoblotting methods fortesting non-alcoholic beverages components on AhR and

GM - Potravinářství

  • 2010 - 2012
    • •
  • 2 877 tis. Kč
    • •
  • 2 877 tis. Kč
    • •
  • GA ČR
Project

The role of intestinal microbiome indole metabolites in the control of gastro-hepatic regulation of lipid and xenobiotic metabolism (GA19-00236S)

and PXR. Therefore, the present project aims to investigate the impact of microbial, endogenous and xenobiotic indoles on the regulatory roles for AhR/PXR in the control both regulation of principal enzymes regulated via AhR/PX...

Cell biology

  • 2019 - 2021
    • •
  • 9 271 tis. Kč
    • •
  • 9 194 tis. Kč
    • •
  • GA ČR
Project

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy (GAP303/12/0472)

CYP3A4 enzyme is the most important enzyme of drug/xenobiotic biotransformation, which metabolizes almost 50% of commonly used drugs. Nuclear receptors (NRs) such as Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are th...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 7 548 tis. Kč
    • •
  • 7 548 tis. Kč
    • •
  • GA ČR
Project

Generation of hepatocyte-derived cellular models for preclinical testing of drugs (GAP304/10/0149)

transporters, ii) inducibility of PXR, CAR and AhR target genes by prototypical compounds...

FR - Farmakologie a lékárnická chemie

  • 2010 - 2012
    • •
  • 4 499 tis. Kč
    • •
  • 4 499 tis. Kč
    • •
  • GA ČR
Project

Enantiospecific interactions between clinically used chiral drugs and regulatory pathways of human cytochromes P450. (GA13-01809S)

-warfarin activates PXR and induces CYP3A4, while therapeutically more active S-warfarin on the enantiospecific interactions between chiral clinically used drugs and xenoreceptors (PXR, AhR......

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 725 tis. Kč
    • •
  • 9 725 tis. Kč
    • •
  • GA ČR
Project

INTERACTIONS OF ESSENTIAL OILS FROM CULINARY SPICES AND HERBS WITH ENDOCRINE AND DETOXICATION SIGNALLING PATHWAYS (GA17-02718S)

on transcriptional activities and functions of receptors AhR, PXR, CAR, GR, AR, VDR and TR effects of estrogens and pesticides on PXR. Given the exposure to herbs and spices......

GM - Potravinářství

  • 2017 - 2019
    • •
  • 4 888 tis. Kč
    • •
  • 4 800 tis. Kč
    • •
  • GA ČR
Project

Pharmacogenetics analgetic efficacy of tramadol in acute pain treatment. (GP305/08/P069)

of known functional polymorphisms in MDR1, PXR or u-opioid receptor genes have not been...

FR - Farmakologie a lékárnická chemie

  • 2008 - 2010
    • •
  • 1 335 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • GA ČR
Project

Non-conventional environmental Ah receptor ligands and their complex effects in vitro (GA21-00533S)

with the human AhR; their so far unexplored impact on the nuclear receptors PXR and CAR, key...

Environmental sciences (social aspects to be 5.7)

  • 2021 - 2023
    • •
  • 8 622 tis. Kč
    • •
  • 8 622 tis. Kč
    • •
  • GA ČR
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