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6 473 (0,162s) •

Project

Targeting BCR signalosome in B-cell malignancies (NV17-31834A)

The B-cell receptor (BCR) signalling pathway is tightly connected with the function, proliferation and survival of B cells. Aberrant BCR signalling, typical for various B cell malignancies

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 9 122 tis. Kč
    • •
  • 9 122 tis. Kč
    • •
  • MZ
Project

Cellular Aging in haematological malignancy (NT14310)

by whole genome assay for B cell progenitors in young and old healthy donors. The aging-biomarkers for B cell progenitors will be identified. B cell aging-diagnostic panel will be generated and v...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 8 570 tis. Kč
    • •
  • 8 511 tis. Kč
    • •
  • MZ
Project

Composition of immunocompetent cells in targeted therapy in pediatric acute lymphoblastic leukemia and lymphoma (NU23-05-00353)

of utmost importance. Targeting specific structures on malignant B cells also influences non-malignant cells. Knowledge about immune reconstitution is essential for identification of patients with preexis...

Immunology

  • 2023 - 2026
    • •
  • 11 022 tis. Kč
    • •
  • 11 022 tis. Kč
    • •
  • MZ
Project

Phenotype feature of B cells and plasma cells and its association with malignant transformation in monoclonal gammopathies (NS10408)

Flow cytometric analysis of B cells and plasma cells subtypes in healthy volunteers and monoclonal gammopathy patients. Identification of clonal cells in compartment of plasma cells or B cells...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 3 582 tis. Kč
    • •
  • 3 582 tis. Kč
    • •
  • MZ
Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating B-cell malignancies, yet, their long term efficiency does not hold up to the original promises. Novel designs of CAR-T cells ...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of signaling through leukocyte receptors their role in health and disease. (GBP302/12/G101)

). Functional analysis of human B-cell development and B-cell receptor assembly and editing and B-cell interplay with T-lymphocytes in relation to B cell malignant of im...

EC - Imunologie

  • 2012 - 2018
    • •
  • 75 061 tis. Kč
    • •
  • 75 061 tis. Kč
    • •
  • GA ČR
Project

THE IMPACT OF THERAPEUTIC TARGETING OF BCR SIGNALLING ON GENE EXPRESSION IN B CELL MALIGNANCIES AND ITS PROGNOSTIC AND PREDICTIVE SIGNIFICANCE (NV16-29622A)

The clinical use of BCR-inhibitors in B cell malignancies has promising clinical effects; however, better understanding is needed to design combinatorial treatments, and to understand their mechanisms of action and molecula...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 9 899 tis. Kč
    • •
  • 9 899 tis. Kč
    • •
  • MZ
Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

that enhance the immunogenicity of B-CLL cells may be useful in immunotherapeutic approaches to this disease. Non-malignant B cells express broad spectrum of Toll-like incurable with conventional therapy....

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

ROR1-positive peripheral blood b-cells of healthy donors and their connection to chronic lymphocytic leukemia development (GA23-05561S)

+ B cells were described, however our data show that these populations contain also mature B cells, including memory subsets. We will analyze these populations together with peripheral B cells of ...

Cell biology

  • 2023 - 2025
    • •
  • 10 232 tis. Kč
    • •
  • 10 232 tis. Kč
    • •
  • GA ČR
Project

Molecular Characterization of B-cell Receptors and Their Relationship to Evolution of Gemonic Aberrations in Chronic Lymphocytic Leukemia (NT13493)

factors. The signalization via B-cell receptor (BCR) belongs among them; its intensity potential of malignant cells which influence heterogeneous accumulation of genetic single-cell multiplex PCR for comp...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 8 737 tis. Kč
    • •
  • 8 737 tis. Kč
    • •
  • MZ
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