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1 806 (0,083s) •

Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

and mortality. OXPHOS biogenesis is under dual genetic control, mitochondrial DNA (mtDNA) and nuclear genome. Subgroup of MD is characterized by mtDNA instability. MtDNA deletions may be caused by mutations in nuc...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

Mitochondrial and nuclear DNA cross-talk and its impact on metabolic phenotype and innate immunity (GA19-10354S)

circular DNA (mtDNA). Human mtDNA exerts considerable sequence variability dividing the population into different mtDNA subpopulations known as haplogroups. Recently, many studies suggested that mtDNA m...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2022
    • •
  • 6 634 tis. Kč
    • •
  • 6 580 tis. Kč
    • •
  • GA ČR
Project

Precision Control of Mitochondrial DNA via Structure–Sequence Integration for Medical Applications (LUAKR25078)

1. Identify and Characterize Local DNA Structures: To identify and characterize local DNA structures, such as G-quadruplexes and inverted repeats forming cruciforms, within mitochondrial DNA (mtDNA). This includes ...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 4 869 tis. Kč
    • •
  • 4 869 tis. Kč
    • •
  • MŠMT
Project

Mitochondiral diseases caused by depletion and mutation of mitochondrial DNA (ME 226)

are problematic due to complicated genetics of the mitochondrial DNA (mtDNA) genes. The aim mtDNA defects, namely depletion of mtDNA and mutations in tRNA, cytochrome c oxidase and ATPase genes. Functional studies...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 1 040 tis. Kč
    • •
  • 389 tis. Kč
    • •
  • MŠMT
Project

Properties of horizontal mitochondrial transfer in cancer (GJ18-24753Y)

in the form of mitochondrial DNA (mtDNA). Cell type mtDNA heteroplasmy was reported before cells. Cellular mtDNA heterogeneity and transport are potentially connected in both for therapy. Our mouse strains with sp...

Cell biology

  • 2018 - 2022
    • •
  • 5 898 tis. Kč
    • •
  • 5 898 tis. Kč
    • •
  • GA ČR
Project

Significance of mitochondrial DNA in colorectal cancer (NU22J-03-00033)

In this project, we will focus on the study of mitochondrial DNA (mtDNA, and aging. Since mitochondria contain their own DNA, they could serve as a candidate in mtDNA have already been identified in several solid c...

Genetics and heredity (medical genetics to be 3)

  • 2022 - 2025
    • •
  • 6 506 tis. Kč
    • •
  • 6 506 tis. Kč
    • •
  • MZ
Project

Genetice and metabolic consequences ofinherited disorders of mitochondrial ATFase. (NE6533)

Genetic and funtional characterization of mitochondrial encephalomyopathies caused by specific functional defects of mitochondrial ATP synthase due to mutations in mtDNA gene of subunit a, or by nuclear defects affecting biosynthesis of the ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 4 947 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Project

The significance of mitochondriál DNA mutations in the pathogenesis of refractory anaemia with ring sideroblasts (NC6001)

Pathogenetical part:1.isolation of mitochondrial fraction from erythroid cwlls in bone marrow,2.detection of mtDNA mutations vy RFLP,3.determinantion of activity and quantity of enzymes of respiratory chain. Clinical part:1.correlation betwe...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • MZ
Project

Genetic analysis of the role of mitochondria in the pathogenesis of metabolic syndrome studied in new rat conplastic strains (GA301/08/0166)

Recently, the potential role of mitochondrial DNA (mtDNA) variants in common and the metabolic syndrome. Preliminary analysis of mtDNA sequence from SHR and Brown Norway (BN (SHRxBN)F1 females with identical nuclear genomes...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 6 896 tis. Kč
    • •
  • 6 896 tis. Kč
    • •
  • GA ČR
Project

Acquisition of the mitochondrial genome by cells with damaged mitochondrial DNA restores the mitochondrial function and tumorigenic capacity (GA15-02203S)

We found that metastatic breast cancer and melanoma cells devoid of mtDNA form found to acquire mtDNA of the host origin, indicating intercellular transfer of mitochondria. mtDNA acquisition resulted in gradual recovery in ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 897 tis. Kč
    • •
  • 6 897 tis. Kč
    • •
  • GA ČR
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