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9 221 (0,179s) •

Project

Fatty acid- and glucose-induced changes in gene expression of peroxisome proliferator-activated receptor (PPAR) signalling cascade molecules (OC 153)

investigation of effects of major energetic substrates on gene expression of major molecular components of signalling molecules...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 2 910 tis. Kč
    • •
  • 1 895 tis. Kč
    • •
  • MŠMT
Project

Effect of simultaneous administration of energy substrates on glucose, fat and protein metabolism in patients with insulin resistance. (NB4903)

The aim of the study is to evaluate the effect of lipid emulsion containing long chain fatty acid (LCT) and middle plus long chain fatty acids (MCT/LCT) on glucose utilisation, oxidation of glucose

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 4 572 tis. Kč
    • •
  • 4 291 tis. Kč
    • •
  • MZ
Project

Modulation of insulin sensitivity by n-3 polyunsaturated fatty acids involvement of adiponectin and AMPK (GA303/07/0708)

kinase (AMPK) to stimulate fatty acid oxidation and glucose transport in muscle that long-chain polyunsaturated fatty acids of n-3 series (n-3 LC-PUFA) from marine fish oils could ameliorate IR induce...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 3 032 tis. Kč
    • •
  • 3 032 tis. Kč
    • •
  • GA ČR
Project

Postprandial lipemia and atherosclerosis prediction (NT14027)

In the study in 30 healthy volunteers it will be investigated how insulin secretion induced by carbohydrate administration affects the magnitude and dynamics of changes of principal parameters of postprandial lipemia (triglyceride, ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 4 968 tis. Kč
    • •
  • 4 968 tis. Kč
    • •
  • MZ
Project

Glucose homeostasis disorders and pancreatic cancer new genetic and nutrition markers related to its occurrence and prognosis (NR9528)

In patients with pancreatic cancer (PC) we will study the polymorphisms -23Hpl (T/A) of the insulin gene promotor, selected adipokins (leptin, adiponectin, TNF-alfa), polyunsaturated fatty acids of plasma phospholipids and the g...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 6 286 tis. Kč
    • •
  • 6 064 tis. Kč
    • •
  • MZ
Project

The effect of acute hyperinsulinaemia on susceptibility to oxidation and fatty acid composition of low-density lipoprotein in the offspring of hypertensive pare (NB4888)

of acutely induced hyperinsulinaemia on LDL oxidability and the fatty acid patternThe aim of the study is to compare the susceptibility to oxidation and fatty acid compostion of LDL in the offsprig of hyp...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 2 148 tis. Kč
    • •
  • 1 804 tis. Kč
    • •
  • MZ
Project

Selected genetic and nutritional factors in pathogenesis of metabolic syndrome importance of polyunsaturated fatty acids. (NT13199)

Decreased content of long chain polyunsaturated fatty acids (LCPUFA) is one depends on dietary intakes of linoleic and a-linolenic acids and enzymatic activities abundance of its components and phenotype:dyslipidemia(i);dis...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 8 323 tis. Kč
    • •
  • 8 323 tis. Kč
    • •
  • MZ
Project

Using 13C and proton MR spectroscopy to study the role of fatty acid transport and accumulation in tissues in the pathogenesis of insulin resistance (GAP301/11/2418)

milieu may induce cellular stress, potentiates oxidative stress and activates inflammatory processes. Using 13C MR spectroscopy, we will study the role of fatty acid with a deletion or increased expression of fatty

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2014
    • •
  • 5 272 tis. Kč
    • •
  • 5 272 tis. Kč
    • •
  • GA ČR
Project

Anti-inflammatory effects of novel lipokines of fatty acid esters of hydroxy fatty acids family in obesity (GJ17-10088Y)

polyunsaturated fatty acids (PUFA) play an important role in resolution of inflammation - fatty acid esters of hydroxy fatty acids (FAHFA) derived from palmitic and stearic acid with ant...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2019
    • •
  • 5 609 tis. Kč
    • •
  • 5 609 tis. Kč
    • •
  • GA ČR
Project

Role of fatty acid binding proteins in pathophysiology of insulin resistance in humans (NR7880)

To measure the expression s of fatty acid-bunding proteins in monocytes and adipose tissue in relation to metabolism of fatty acids and selected clinical. The aim ofthe study is to test the effect of in vivo in...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 882 tis. Kč
    • •
  • 5 560 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 9 221