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58 (0,053s)

Project

Automatic analysis of microscopy images of Langerhans islets (GA14-10440S)

Transplantation of isolated islets of Langerhans is an experimental treatment, the novel algorithm will be available free of charge to the Langerhans islet community evaluation of the quantity and shape of the isol...

JD - Využití počítačů, robotika a její aplikace

  • 2014 - 2018
  • 3 865 tis. Kč
  • 3 865 tis. Kč
  • GA ČR
Project

Respiration, oxidative stress and mitochondrial morphology of Langerhans islets suited for transplantation (NS10219)

To improve prognosis of Langerhans islet (LI) transplantation we'll study cell biology and in situ bioenergetics of their beta cells during glucose-stimulated insulin secretion (GSIS) and conditions of the oxidative stress and apopt...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2009 - 2011
  • 6 732 tis. Kč
  • 6 472 tis. Kč
  • MZ
Project

Mitochondrial morphology a its changes in diabetes (NR9183)

evaluate possibilities of similar diagnostics for Langerhans islets for a possible, isolated rat Langerhans islets, Zucker diabetic fatty and Goto-Kakizaki rats.......

EA - Morfologické obory a cytologie

  • 2007 - 2009
  • 6 017 tis. Kč
  • 5 914 tis. Kč
  • MZ
Project

Optimalization of the culture conditions of the isolated Langerhans islets for transplantation (NT13099)

We will test new methods of protection and cultivation of isolated pancreatic islets designed for transplant therapy of diabetes using the following modifications inhibitors and the use of mesenchymal stem cells conditioned medium for is...

FJ - Chirurgie včetně transplantologie

  • 2012 - 2015
  • 7 019 tis. Kč
  • 6 936 tis. Kč
  • MZ
Project

Role of mitochondrial reactive oxygen species in regulation of pancreatic beta cell function (GPP304/10/P204)

The aim of the suggested project is to find new correlations between bioenergetics, mitochondrial ROS generation, and glucose stimulated insulin response (GSIS) in pancreatic b-cells and Langerhans islets (LI). We intend to establis...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
  • 1 491 tis. Kč
  • 1 491 tis. Kč
  • GA ČR
Project

Evaluation of new transplant sites for pancreatic islets using non-invasive imaging methods in animal models. (NU22-08-00286)

This project aims to evaluate the survival and function of transplanted islets of Langerhans in new transplant sites that need to be considered for use in human medicine islets at these sites will be compared in animal mode...

Medicinal chemistry

  • 2022 - 2025
  • 12 476 tis. Kč
  • 12 476 tis. Kč
  • MZ
Project

New bimodal nano-structures for combined diagnostics and therapeutics (LD13048)

localization, calculation of number and function of the Islets of Langerhans transplanted will be focused on bimodal compounds which will not have a negative effect on the islets......

FP - Ostatní lékařské obory

  • 2013 - 2015
  • 1 154 tis. Kč
  • 1 154 tis. Kč
  • MŠMT
Project

Regulation of the insulin secretion in polycystic ovary syndrome (NR8759)

Polycystic ovary syndrome (PCOS) is connected with insulin resistance and with disturbed insulin secretion , but the literary data are discrepant. Complex evaluation of the function of Langerhans islets has not been doen till now. W...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
  • 4 918 tis. Kč
  • 4 565 tis. Kč
  • MZ
Project

Mitochondrial DNA in tumors and metabolic syndrome (GPP305/12/P388)

tested on clinically relevant models of hypoxia-adapted tumor cells and on Langerhans islets from diabetic rats....

EB - Genetika a molekulární biologie

  • 2012 - 2014
  • 2 460 tis. Kč
  • 2 460 tis. Kč
  • GA ČR
Project

Development of specialized application for the purposes of directing nutritional support and physical activity involved in prehabilitation of patients indicated for solid organ transplantation. (TQ15000313)

and quality of life after kidney, pancreas, islet of Langerhans or liver transplantation...

Endocrinology and metabolism (including diabetes, hormones)

  • 2025 - 2026
  • 5 736 tis. Kč
  • 4 854 tis. Kč
  • TA ČR
  • 1 - 10 out of 58