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10 (0,061s) •

Project

Aurora kinases and their role in cell division of acentrosomal plant cells (GP204/09/P155)

The Aurora kinase family presents a serine/threonine protein kinases organization machinery. The Aurora kinases as a crutial players in cell proliferation Aurora kinases have been analyzed, plant Aurora kinases are...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 098 tis. Kč
    • •
  • 1 098 tis. Kč
    • •
  • GA ČR
Project

Spindle dynamics and chromosome segregation during oocyte meiotic maturation (LTAUSA17097)

The goal of the project is to understand of the role of the Aurora kinases: 1. Role of Ran.GTP in spindle formation and maintenance 2. Function of Aurora-A - CDC25B signalling in spindle integrity 3. Role of Aurora kinase ...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 7 519 tis. Kč
    • •
  • 6 461 tis. Kč
    • •
  • MŠMT
Project

The role of protein kinase Aurora-A in resumption of meiosis of mouse oocytes. (GA305/06/1413)

phosphatases: CDC25B and C. Phosphorylation of CDC25B by Aurora-A kinase on centrosome experiments: i/ to follow expression and activation of Aurora-A and its regulator LIM......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • GA ČR
Project

Signaling pathways regulating genome integrity during oocyte-to-embryo transition (GA25-18241S)

in accurate chromosome segregation in early mouse embryos. We will focus on Aurora kinases to this, and the cooperation between CHK1 and Aurora kinases.......

Cell biology

  • 2025 - 2027
    • •
  • 8 121 tis. Kč
    • •
  • 8 121 tis. Kč
    • •
  • GA ČR
Project

Phosphorylation-mediated signalling in DNA damage response and cancer (7F14061)

In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phosphatase in DNA d...

FD - Onkologie a hematologie

  • 2014 - 2017
    • •
  • 25 520 tis. Kč
    • •
  • 25 520 tis. Kč
    • •
  • MŠMT
Project

Regions of dense plasma in the magnetospheric tail (GA202/97/P076)

The magnetospheric tail plays an important role in the transport of energy and mass from the Sun to the Earth's magnetosphere and ionosphere. Many key magnetospheric processes (as substorms) originate in the tail, as well as more subtle phenomena (li...

BL - Fyzika plasmatu a výboje v plynech

  • 1997 - 1999
    • •
  • 491 tis. Kč
    • •
  • 331 tis. Kč
    • •
  • GA ČR
Project

Characterization of factors regulating chromatin condensation during meiotic maturation of pig and cattle oocytes (GA204/03/0816)

In this project we propose to follow changes of histone H1 and H3 phosphorylation, expression and activity of Aurora B kinase, as well as the expression and phosphorylation status of the different subunits of 13S condensin complex in correla...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 2 318 tis. Kč
    • •
  • 1 454 tis. Kč
    • •
  • GA ČR
Project

The changes in chromatin structure during meiotic maturation of pig oocytes correlation to chromosomal aneuploidy (GA204/06/1297)

In this project we propose to follow the mechanisms involved in the regulation of the changes in chromatin structure and conformation during meiotic maturation of pig oocytes; we will study the role of posttranslational modification(s) of 13S condens...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 2 308 tis. Kč
    • •
  • 2 308 tis. Kč
    • •
  • GA ČR
Project

Regulation of acentriolar spindle assembly and chromosome segregation in human and mouse oocyte meiosis (GA23-07532S)

structures called liquid-like spindle domains (LISD). The Aurora kinases (AURKs...

Cell biology

  • 2023 - 2025
    • •
  • 7 402 tis. Kč
    • •
  • 7 402 tis. Kč
    • •
  • GA ČR
Project

Regulation of translation initiation during meiotic maturation of pig oocytes by protein factors associated with mRNA 3'-end (GA524/07/1087)

predominates, when it is phosphorylated by Aurora A kinase. This event induces CPEB to bind...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 2 335 tis. Kč
    • •
  • 2 335 tis. Kč
    • •
  • GA ČR
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