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7 667 (0,151s) •

Project

Peptide Killers of Bacteria (LL2007)

We will develop a method for the targeting of peptides to membranes with specific lipid composition and determine key peptide properties for membrane translocation and pore formation. The designed peptides will be ...

Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

  • 2020 - 2021
    • •
  • 13 476 tis. Kč
    • •
  • 13 476 tis. Kč
    • •
  • MŠMT
Project

Polymer terapeutics based on antimicrobial peptides for multi-resistence bakteria species treatment (GA20-04790S)

of the system structure and peptide release onto its properties should facilitate designingThe project focuses on design, synthesizes and study the physico-chemical and biological properties of novel biodegradable star pol...

Polymer science

  • 2020 - 2022
    • •
  • 5 461 tis. Kč
    • •
  • 5 461 tis. Kč
    • •
  • GA ČR
Project

Design, synthesis, screening and functional study of peptides with high affinity to heavy metals;their presentation on bacterial surface (GA203/98/0650)

of peptide fragments that show improved binding characteristics for specific heavy metals on the synthesis of peptides using combinatorial chemistry. This will be done by synthesis and screening of peptide libraries. Paral...

CE - Biochemie

  • 1998 - 2000
    • •
  • 1 996 tis. Kč
    • •
  • 1 849 tis. Kč
    • •
  • GA ČR
Project

Amphiphilic Peptides at Phospholipid Membranes (GA17-11571S)

of peptide behavior at the membrane will be useful for the rational design of peptides barrier function, which can be altered by interaction with amphiphilic peptides. In particular, antimicrobial and cell-penetra...

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2021
    • •
  • 4 803 tis. Kč
    • •
  • 4 803 tis. Kč
    • •
  • GA ČR
Project

Research of Therapeutic Radiopharmaceuticals Based on Labeled Peptides with 177Lu (7AMB14AR009)

of methods for peptides derivatives conjugation and purification methods, suitable chelating ligands selection, study of characteristic of prepared peptides conjugates prepared radiopharmaceuticals and mutual testing. Joint des...

CH - Jaderná a kvantová chemie, fotochemie

  • 2014 - 2015
    • •
  • 148 tis. Kč
    • •
  • 148 tis. Kč
    • •
  • MŠMT
Project

New antifungal peptides for treatment of diseases caused by yeast pathogens (TA04010638)

, biochemistry, microbiology and biophysics, these new peptides will be designed, synthesized, tested in vitro and in vivo. In addition, synergistic effect of antifungal peptidesThe project is aiming to the synthesis of nov...

EE - Mikrobiologie, virologie

  • 2014 - 2016
    • •
  • 7 182 tis. Kč
    • •
  • 4 500 tis. Kč
    • •
  • TA ČR
Project

Design of novel peptidic inhibitors of cysteine and aspartic proteases (GP203/01/D008)

willbe designed de novo using technology of combinatorial peptide libraries. Further, rational design will be performed based on propart "activation" peptides and molecularThe project is focused on design...

CE - Biochemie

  • 2001 - 2004
    • •
  • 846 tis. Kč
    • •
  • 605 tis. Kč
    • •
  • GA ČR
Project

Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases (8X25063)

The project's overall objective is to identify LEA-based proteins/peptides) Identification of LEAPs/Aβ40 and LEAP/α-Syn binding interface and design of LEA-based peptides (iv) Assessment of the toxicity and overall effects ...

Biophysics

  • 2025 - 2027
    • •
  • 246 tis. Kč
    • •
  • 246 tis. Kč
    • •
  • MŠMT
Project

Hybrid macromolecular systems based on hydrophilic polymers and stimuli-responsive peptides (GA203/08/0543)

environment (e.g., temperature, pH, ionic strength). The peptide sequences designed of block copolymers consisting of hydrophilic synthetic polymers and peptides preparedby solid phase synthesis is suggested. The pepti...

CC - Organická chemie

  • 2008 - 2011
    • •
  • 4 295 tis. Kč
    • •
  • 4 295 tis. Kč
    • •
  • GA ČR
Project

Rational design and synthesis of retroviral proteinase inhibitors derived from natural peptide substrates by modification of an amide bond (IA455101)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
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