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756 (0,151s) •

Project

Discovery libraries of chemical compounds. (FT-TA2/054)

A new laboratory of combinatorial chemistry will be established in ICT Prague. A team of scientists in cooperation of ICT Prague and RE&D VÚFB, Ltd. will be working on new methods of parallel syntheses and dynamic combinatorial ...

CC - Organická chemie

  • 2005 - 2008
    • •
  • 10 633 tis. Kč
    • •
  • 6 525 tis. Kč
    • •
  • MPO
Project

Combinatorial libraries - rational approach to preparation of receptors (GP203/03/D049)

. Such compounds will be used for preparation of combinatorial libraries and/or dynamic combinatorial libraries. By using of combinatorial libraries we expect significantly higher efficiency of re...

CB - Analytická chemie, separace

  • 2003 - 2006
    • •
  • 706 tis. Kč
    • •
  • 706 tis. Kč
    • •
  • GA ČR
Project

Application of combinatorial libraries of phosphinic pseudopeptides for isolation and purification of new Zn-metalloproteases (GA203/97/0039)

We propose a new method of isolation, purification and characterization of unknown Zn-metalloproteases with the use of immobilized combinatorial libraries of of phosphinic pseudopeptides of a general formula Yaa-Xaa (PO2CH2)Xaa'-Yaa...

CC - Organická chemie

  • 1997 - 1999
    • •
  • 1 330 tis. Kč
    • •
  • 764 tis. Kč
    • •
  • GA ČR
Project

System for searching for new biologically active compounds. Foccused combinatorial libraries. (FT-TA5/136)

IMG AS CR owns a unique technology for high-throughput screening for biological activity. RE&D VUFB company is experienced in medicinal chemistry and builds the technology for parallel synthesis combinatorial chemistry. In this co-operation ...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 11 224 tis. Kč
    • •
  • 7 127 tis. Kč
    • •
  • MPO
Project

Non-natural inhibitors of physiologically important protein interaction systems based on synthetic combinatorial libraries (GA203/97/1025)

Combinatorial libraries are new methods for efficient synthesis and screening of large pools of chemical compounds generated by random combinations of building blocks. The libraries are a potential source of biologically ac...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 711 tis. Kč
    • •
  • 1 776 tis. Kč
    • •
  • GA ČR
Project

Combinatorial chemistry in research and education (EE2.3.20.0009)

The aim is to establish research team that will deal with solid-phase synthesis and combinatorial chemistry. The new team will develop a modern chemical methods and instrumental tools for the preparation of chemical libraries. The p...

CB - Analytická chemie, separace

  • 2011 - 2014
    • •
  • 21 446 tis. Kč
    • •
  • 21 446 tis. Kč
    • •
  • MŠMT
Project

Combinatorial chemistry in design of novel modulators of glycosidases function (OC D16.001)

The synthetic combinatorial libraries will be used for design of novel low-molecular weight inhibitors of glycosidases. The mimetics represent more effective and specific alternative to natural glycosidases inhibitors of saccharidic...

CE - Biochemie

  • 2002 - 2004
    • •
  • 1 509 tis. Kč
    • •
  • 1 006 tis. Kč
    • •
  • MŠMT
Project

Application of combinatorial libraries of affinity carriers for the identificatio of new interactions of the protein-ligand type (IAB4055003)

to prepare combinatorial libraries of immobilized phosphinic pseudopeptides which...

CE - Biochemie

  • 2000 - 2002
    • •
  • 2 242 tis. Kč
    • •
  • 1 384 tis. Kč
    • •
  • AV ČR
Project

Combinatorial approach to myelin and/or beta-sheet breakers. Implication for the therapeutic approaches to Alzheiner's and prion diseases (GA203/02/1379)

The project is divided into the synthetic, biological and physico-chemical parts . In the synthetic part we intent to carry out the synthesis of bis-intercalator peptide library functionalized with 9-amino acridine and to prepare a peptide p...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 840 tis. Kč
    • •
  • 1 327 tis. Kč
    • •
  • GA ČR
Project

Synthesis and screening of selective probes for magnetic resonance imaging (GJ17-22834Y)

chains. Combinatorial synthesis on solid phase will be used to prepare libraries of the chelate. A new approach is proposed for screening of compound libraries directly......

CC - Organická chemie

  • 2017 - 2021
    • •
  • 5 331 tis. Kč
    • •
  • 5 331 tis. Kč
    • •
  • GA ČR
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