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152 (0,104s) •

Project

FtsH proteases and their function in the cyanobacterium Synechocystis PCC 6803 (IAA400200801)

ATP-dependent proteases FtsH are involved in the quality control of proteins degradation,contains four genes encoding FtsH homologues. The protease encoded FtsH proteases encoded by the slr1604 an...

CE - Biochemie

  • 2008 - 2011
    • •
  • 2 274 tis. Kč
    • •
  • 2 274 tis. Kč
    • •
  • AV ČR
Project

The role of FtsH proteases in biogenesis of thylakoid membranes and photosynthetic complexes in cyanobacteria (GJ19-08900Y)

FtsHs are universally conserved transmembrane metalloproteases. In plants. In cyanobacteria, FtsHs are mostly known for PSII repair during photoinhibition. Our preliminary results, however, indicate that cyanobacterial FtsHs

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 5 445 tis. Kč
    • •
  • 5 445 tis. Kč
    • •
  • GA ČR
Project

Role of the protease slr0228 in the degradation of Photosystem II proteins in the cyanobacterium Synechocystis (GA203/04/0800)

by a reversal assembly of the complex. All these steps require presence of proteases of the process. The aim of the project is to elucidate a role of one of the four FtsH protease homologues encoded by the slr0228 gene in ...

CE - Biochemie

  • 2004 - 2006
    • •
  • 1 716 tis. Kč
    • •
  • 1 716 tis. Kč
    • •
  • GA ČR
Project

Digestive enzymes of Schistosoma_ New target for the treatment of parasitic (KJB400550516)

proteases critical for metabolism of Schistosoma. The selected proteases. The activation process will be analyzed for the protease zymogens processed to the mature for interactionwith the active site of the protease

CE - Biochemie

  • 2005 - 2007
    • •
  • 888 tis. Kč
    • •
  • 888 tis. Kč
    • •
  • AV ČR
Project

Detection and characterisation of HIV-1 mutants resistant to specific therapy with protease inhibitors evolution of the resistant species and their interactions with other viral proteins (NI6339)

Resistant HIV strains in patients treated by protease inhibitors. Sequencing, cloning and analysis of recombinant mutant proteases. Design of a broad specificity inhibitor. Co-evolution of protease and pther viral genes in ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 4 431 tis. Kč
    • •
  • 3 170 tis. Kč
    • •
  • MZ
Project

Molecular mechanism of function of proteases in breast cancer (1P04OCB20.002)

The project is on structure-function relationship in cathepsin D protease playing a critical role in breast cancer....

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 400 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • MŠMT
Project

Functional proteomics of plant defense proteins (OC09007)

and their protein-protein interactions. It concentrates on protease inhibitors the enzymatic activity of digestive proteases of insect herbivores. Plant protease for the identification and functional characterization of pl...

CE - Biochemie

  • 2009 - 2011
    • •
  • 1 250 tis. Kč
    • •
  • 1 250 tis. Kč
    • •
  • MŠMT
Project

Analysis of Drug Resistance to HIV-1 Protease Inhibitors (IZ4059)

Resistant mutants of the HIV protease from the blood lymphocytes of AIDS patients treated with protease inhibitors will be amplified, sequenced, characterized in vitro and in tissue culture and tested with a panel of structurally di...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1999
    • •
  • 2 136 tis. Kč
    • •
  • 2 136 tis. Kč
    • •
  • MZ
Project

Using the experimental and theoretical methods for structure analysis of HIV protease complexes with selected inhibitors (IAA4050811)

The aim is the determine structure of HIV protease complexes with selected of the inhibition differences observed with wild and mutated protease and to generalize of wild and mutant protease isolated from patients with deve...

CD - Makromolekulární chemie

  • 1998 - 2001
    • •
  • 7 855 tis. Kč
    • •
  • 3 428 tis. Kč
    • •
  • AV ČR
Project

Insights into the dynamics of the ATP-dependent human mitochondrial Lon protease by its three-dimensional electron microscopic structural analysis (GP13-32339P)

Lon proteases are the most flexible ATP-dependent proteases, which are both of these proteases are linked with dystrophies, neurodegenerative diseases and cancer. A deeper-ase cycle. 3D structure of any flexible Lon pro...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 2 835 tis. Kč
    • •
  • 2 835 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 152