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4 872 (0,181s) •

Project

Benzophenanthridine alkaloids - study of their effects on cellular and molecular level (LH12176)

The aim of the project is to study benzophenanthridine alkaloids from the selected plant species in cooperation with chinese partner. The first aim is obtaining these alkaloids in sufficient amount. This assumes analysis of selected plant growing in ...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 3 007 tis. Kč
    • •
  • 3 007 tis. Kč
    • •
  • MŠMT
Project

Protein-DNA Complexes and Force Field Development (GA20-28231S)

with developing force fields (FF) for nucleic acid (NA) simulations. Current NA FFs are known to suffer from intrinsic difficulties in describing non-canonical DNA and RNA motifs known A-DNA-like or BII-DNA motifs...

Physical chemistry

  • 2020 - 2022
    • •
  • 2 687 tis. Kč
    • •
  • 2 687 tis. Kč
    • •
  • GA ČR
Project

The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia (NT11217)

The proposed project attempts to clarify the role of non-canonical Wnt pathway are these parameters modulated by directed modulation of non-canonical Wnt signaling.). The proposed goal will be achieved by expressio...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 9 860 tis. Kč
    • •
  • 9 860 tis. Kč
    • •
  • MZ
Project

Dynamic polymorphism of non-canonical nucleic acids structures in the intracellular space (GF24-10605K)

, the structural characterization of non-canonical NA dynamic polymorphism has relied...

Biochemical research methods

  • 2024 - 2027
    • •
  • 10 419 tis. Kč
    • •
  • 10 203 tis. Kč
    • •
  • GA ČR
Project

In vitro and in silico identification of non-canonical DNA structures in genomic DNA sequences (GA204/08/1560)

Genomic sequencing generated an increased interest in non-coding DNA. This applies also to non-canonical DNA structures and their possible biological functions. Here we propose to combine molecular biology, bioinformatics a...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 647 tis. Kč
    • •
  • 2 647 tis. Kč
    • •
  • GA ČR
Project

Synthesis and Biophysical Analysis of Oligoribonucleotides and the Corresponding Oligodeoxy-Ribonucleotides Containing Non-Canonical Bases. (GA203/94/0646)

BO - Biofyzika

  • 1994 - 1996
    • •
  • 725 tis. Kč
    • •
  • 1 025 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways. Here we propose to expand our previous studies by focusing on molecular mechanisms of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Ce...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

RNA editing in non-model flagellates (GA22-01026S)

Armed with new tools to analyze canonical and non-canonical RNA editing at the level of singular events, we will study this process in non-model trypanosomatids and other euglenozoans. In addition, we propose to sc...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 432 tis. Kč
    • •
  • 8 906 tis. Kč
    • •
  • GA ČR
Project

Exploring non-canonical ORFs with functions in DNA damage repair (EH22_010/0008995)

The number of annotated genes has not changed significantly since the sequencing of the human genome 20 years ago. However, recent technological advances have revealed that our genome's protein-coding capacity is greater than previously thought, givin...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2028
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
Project

Time-resolved vibrational spectroscopy of proteins assisted by genetically encoded non-canonical amino acids (GA24-11819S)

strategy to initiate and monitor non-equilibrium protein structural dynamics based on genetically encoded non-canonical amino acids (ncAA). We will incorporate novel ncAA......

Biophysics

  • 2024 - 2026
    • •
  • 8 160 tis. Kč
    • •
  • 8 160 tis. Kč
    • •
  • GA ČR
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