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Influence of conformation and chemical modification on the behavior of oligonucleotides at electrodes towards the development of DNA sensors (GAP206/12/2378)
of model ON. Similarly will be studied influence of chemical modification. This study will include not only modification of DNA bases (metal complexes, organic functional groups), but also modification of DNA<...
CB - Analytická chemie, separace
- 2012 - 2016 •
- 5 517 tis. Kč •
- 5 517 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 7. 4. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins (GA15-21855S)
modifications and local DNA structures (cruciform, triplexes and quadruplexes) on protein modifications and with local DNA structures. We assume that our results will enhance ourAn altered pattern of epigenetic
EB - Genetika a molekulární biologie
- 2015 - 2017 •
- 6 795 tis. Kč •
- 6 795 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Influence of chemical modification of DNA and synthetic oligonucleotides on their electrochemical behaviour (GA204/00/D049)
Knowledge about influence of chemical modification of DNA and synthetic oligonucleotides on their electrochemical behaviour are important for construction of the sensors for specific interactions of DNA (include DNA
CE - Biochemie
- 2000 - 2003 •
- 1 231 tis. Kč •
- 719 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2000 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (58%)
Poskytovatel: Grantová agentura České republiky
Electroactive and fluorescent modifications of nucleic acids for structure & interaction studies and for applications in diagnostics (GA22-11252S)
to modify NA; (3) influence of specific DNA modifications on its structures and chemical modification (e.g., possibility of reduction of NA bases at carbon electrodes, new findings on electrocatalytic processes, establishi...
Analytical chemistry
- 2022 - 2024 •
- 11 476 tis. Kč •
- 11 215 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Artificial epigenetics Development of a eukaryotic bioorthogonal transcription system for gene expression manipulation in the cell. (GA17-03419S)
Natural DNA modifications are epigenetic signals that are vital for regulation of gene expression. Artificial DNA modifications possess immense potential with respect to modulate the way how RNA polymerase (the key...
EB - Genetika a molekulární biologie
- 2017 - 2019 •
- 9 537 tis. Kč •
- 9 072 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines (GP301/07/P160)
Detailed knowledge of modification and DNA binding activity of p53 protein in detail posttranslational modifications of the p53 protein, influence of p53 modification on its DNA binding and changes of the ...
EB - Genetika a molekulární biologie
- 2007 - 2009 •
- 1 365 tis. Kč •
- 1 365 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Post-translational modifications of Daxx and their functional relevance in DNA damage response and cellular senescence (GPP305/11/P683)
, cellular senescence has been observed to be associated with activation of DNA damage projects that may participate in regulation of DNA damage checkpoints, DNA repair such emerging substrate, and its posttranslational
EB - Genetika a molekulární biologie
- 2011 - 2014 •
- 2 199 tis. Kč •
- 2 199 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Modifications and bioorthogonal reactions in the major groove of DNA for regulation of protein binding and gene expression (GA14-04289S)
by DNA polymerases. The diverse types of modifications will be studied as protecting groups for regulation (switching) of binding of proteins to DNA. The influenceSynthesis of novel base-modified oligonucleotides (ONs) and...
CE - Biochemie
- 2014 - 2016 •
- 9 994 tis. Kč •
- 9 994 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Biophysical Properties of Biologically and Medically Important Regions of Human DNA (IAA100040701)
of specific DNA arrangements and their modification by external conditions, changesDNA can exist in conformations substantially different from the classical is the basis of mechanisms through which DNA controls an...
BO - Biofyzika
- 2007 - 2011 •
- 3 725 tis. Kč •
- 3 725 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)
protein p53 and its binding to DNA. Better understanding of this key protein are directed at: (i) the effect of postsynthetic modifications of the p53 protein on its binding to DNA and particularly to supercoiled DNA
CE - Biochemie
- 2001 - 2004 •
- 4 874 tis. Kč •
- 1 990 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2001 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (41%)
Poskytovatel: Akademie věd České republiky
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