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46 (0,192s) •

Project

Phenomenological criteria of fatigue life under fretting conditions (GA101/09/1709)

Reduced fatigue life is typical for damage process known as fretting (contact) Comparison of chosen published or newly designed phenomenological fretting fatigue of fretting fatigue life prediction according to these criter...

JL - Únava materiálu a lomová mechanika

  • 2009 - 2011
    • •
  • 2 282 tis. Kč
    • •
  • 2 282 tis. Kč
    • •
  • GA ČR
Project

Multi-FRET fluorescent probes responding to hydrolases (GA19-23972S)

The project is focused on synthesis of model systems for detection of two or three proteases solely or in their mixture via fluorescence multi-FRET effect. The systems will be based on three/four dyes connected with linkers cleavable by the ...

Organic chemistry

  • 2019 - 2021
    • •
  • 5 070 tis. Kč
    • •
  • 5 070 tis. Kč
    • •
  • GA ČR
Project

Analysis of Src kinase activation using a novel FRET-based biosensor (GA15-07321S)

the conformational changes following Src activation to construct a genetically encoded FRET based...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 170 tis. Kč
    • •
  • 4 170 tis. Kč
    • •
  • GA ČR
Project

Förster energy transfer in the mutants of uncoupling protein (UcP) - photophysics of single-tryptrophan mutants of UcP (IAA1011601)

(TCSPC), time resolved spectra and Forster resonance energy transfer (FRET) between, for example TrP 173 - Lys 174 will be studied, as well as FRET on mutants from FRET, either from UcP to acceptors located at important po...

BH - Optika, masery a lasery

  • 1996 - 1998
    • •
  • 730 tis. Kč
    • •
  • 546 tis. Kč
    • •
  • AV ČR
Project

Novel anti-Stokes lanthanide nanoparticles and multicolor FRET mechanisms for single-molecule DNA sequencing (GF23-06199K)

aim to develop a new nanoparticle-based multicolor resonant energy transfer (FRET luminescent nanomaterials for multicolor FRET that can be detected without......

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2023 - 2025
    • •
  • 6 525 tis. Kč
    • •
  • 6 525 tis. Kč
    • •
  • GA ČR
Project

Design of fluorescence-based analytical tool for quantification of the protein-protein interaction within the 14-3-3 family (7AMB16DE005)

FRET probes (5) to compare the experimentally determined equilibrium and kinetics...

BO - Biofyzika

  • 2016 - 2017
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Solving the WNT pathway mystery by the analysis of Dishevelled structure (GA18-17658S)

combination of FRET and methods of structural proteomics, and (ii) to produce DVL protein...

Cell biology

  • 2018 - 2020
    • •
  • 7 122 tis. Kč
    • •
  • 6 823 tis. Kč
    • •
  • GA ČR
Project

Study of glutamate receptors conformational changes using novel fluorescent techniques (GA303/08/1591)

The activation mechanism of the metabotropic glutamate receptors and GABAb receptors is studied extensively in our laboratory. We aim to describe molecular events that result from competitive ligand binding or actions of negative and positive alloste...

FR - Farmakologie a lékárnická chemie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
Project

Methods of automatized evaluation of cell viability using advanced microscopic techniques. (TA02011193)

Development of methods of automatized evaluation of cell viability using advanced microscopic techniques. Selection of algorithms appropriate for evaluation of relevant parameters from images obtained by various microscopic techniques.......

IN - Informatika

  • 2012 - 2014
    • •
  • 7 713 tis. Kč
    • •
  • 4 720 tis. Kč
    • •
  • TA ČR
Project

From conformation to biological functions of HP1 protein (GA18-07384S)

by means of FLIM-FRET microscopy as well as biological functions of HP1 proteins...

Cell biology

  • 2018 - 2020
    • •
  • 10 461 tis. Kč
    • •
  • 8 850 tis. Kč
    • •
  • GA ČR
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