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20 (0,187s) •

Project

What cells are responsible for unselected B cell repertoire in the porcine thymus? (GA16-09296S)

for immunoglobulin heavy chain (HC) in the porcine thymus. The reason for existence of such repertoire is a fact that thymus serves as a primary lymphoid organ for T cells that complete HC rearrangement clearly occurs in the th...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2016 - 2020
    • •
  • 6 036 tis. Kč
    • •
  • 6 036 tis. Kč
    • •
  • GA ČR
Project

Inflammation Related Transitional Dendritic Cells as Key Players in T Cell Tolerance (GM25-16606M)

of central immune tolerance that occur in the thymus and are crucial for the formation clones and prevent autoimmunity. However, how the thymus provide tolerance to inflammation-related antigens remains unknown. Our preliminary dat...

Immunology

  • 2025 - 2029
    • •
  • 25 000 tis. Kč
    • •
  • 25 000 tis. Kč
    • •
  • GA ČR
Project

Morphological changes of the fetal thymus and adrenal glands on ultrasound as a marker the systemic fetal inflammatory response syndrome (GA304/09/0494)

. The size of the fetal thymus is decreased but the adrenal glands are increased  in size  in women with chorioamnionitis. Measurement of the fetal thymus and adrenal glands......

FK - Gynekologie a porodnictví

  • 2009 - 2011
    • •
  • 2 169 tis. Kč
    • •
  • 2 169 tis. Kč
    • •
  • GA ČR
Project

Postnatal development of the thymus of nu/nu and nu/+ mice in the electron microscope (GA304/94/1376)

EA - Morfologické obory a cytologie

  • 1994 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • GA ČR
Project

CATCH 22 Immune functions in patients with 22.11q microdeletion and the development of immunity in children with diGeorge syndrome (NI6247)

CATCH 22 is the name for cluster of diseases, syndrome di George included, based on microdeletion in the region 11q on 22 chromosome. We plan to follow the development of immune function in the absence of thymus in children with fiGeorge syn...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 1 361 tis. Kč
    • •
  • 1 361 tis. Kč
    • •
  • MZ
Project

Pathology of thymus with attention to neoplasmatic diseases and changes appearing in so called autoagressive diseases. (IZ1031)

9F - 9

  • 1992 - 1996
    • •
  • 99 tis. Kč
    • •
  • 130 tis. Kč
    • •
  • MZ
Project

The regulation of immunity in syndrome diGeorge (NT13287)

Current proposal covers systematic and prospective immunological investigation of a cohort of children with syndrome diGeorge. As a part of their genetic defect these patient have impaired development of thymus that substantially affects the...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2012 - 2015
    • •
  • 9 183 tis. Kč
    • •
  • 9 183 tis. Kč
    • •
  • MZ
Project

Immunity in pacients with diGeorge syndrome-project II. correlation of genotype and fenotype (NI7410)

Project is the continuation of prospective study of patients with immunodeficiency based on the syndrome diGeorge. The majority of patients has detectable microdeletion on chromosome 22 and subsequent complex symptomatology including missing thym...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 433 tis. Kč
    • •
  • 1 422 tis. Kč
    • •
  • MZ
Project

Development of peripheral gamma delta T lymhocytes in swine (GA524/07/0087)

The aim of the proposed project is to study the development and behavior of porcine gd T cells outside of thymus (so called peripheral gd T lymphocytes). Our are exported from the thymus independently. (2) It is our hypothesis that ...

EC - Imunologie

  • 2007 - 2011
    • •
  • 5 856 tis. Kč
    • •
  • 5 856 tis. Kč
    • •
  • GA ČR
Project

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

Tolerance to “self” is the fundamental property of the immune system. Mechanisms of central tolerance that are operational in the thymus, robustly limit the selfreactive repertoire within the T cell population via deletion of T cells that ex...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
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