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1 619 (0,225s) •

Project

Study of the interaction of C- and N- terminal segments of TRPV1 and TRPV3 channels with phospholipids. (GPP205/10/P308)

TRPV1 and TRPV3 channels are members of the TRP ion channel family. TRP channels are characterized by polymodal activation and its activity could be modulated(4,5)P2) have been found to function as an important reg...

BO - Biofyzika

  • 2010 - 2012
    • •
  • 1 218 tis. Kč
    • •
  • 1 218 tis. Kč
    • •
  • GA ČR
Project

Mutation analysis of candidate genes of long QT syndrome (NR8063)

The Long QT syndrome is a genetically determined disease associated with high risk of malignant ventricular arrhytmias and sudden death. Half of the cases is caused by mutation of genes for 3 myocardial ion channels. Alteration of o...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2004 - 2006
    • •
  • 2 291 tis. Kč
    • •
  • 2 042 tis. Kč
    • •
  • MZ
Project

Regulatory mechanisms of nociceptive transient receptor potential ion channels (GA15-15839S)

/structural properties of nociceptor-specific transduction polymodal temperature-gated ion channels of the transient receptor potential protein family, TRPV3, TRPM3 and TRPA1 the underlying mechanisms responsible for functional modu...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2017
    • •
  • 5 282 tis. Kč
    • •
  • 5 282 tis. Kč
    • •
  • GA ČR
Project

Molecular Basis of Thermosensitive TRP Ion Channel Regulation in Nociceptive Neurons (GA19-03777S)

Thermosensitive Transient Receptor Potential (TRP) channels are excitatory ion channels that function as polymodal cellular sensors, detecting a wide range of proalgesic agents, endogenous products of inflammation and chang...

Neurosciences (including psychophysiology)

  • 2019 - 2021
    • •
  • 6 364 tis. Kč
    • •
  • 6 046 tis. Kč
    • •
  • GA ČR
Project

Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation (GA17-21146S)

of ion channels and receptors in SCs is not fully understood. Our preliminary data neural cells, affects expression of ion channel and receptors which could play of ion channels, receptors and Ca...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 2 755 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

Occurence of myocardial ion channel genes polymorphisms in relationship to sudden cardiac death in patients with structural heart disease (NR9340)

and conduction in myocardium. Myocardial ion channel genes mutations are the cause of increased SCD risk in so called electric heart diseases. In normal population ion) they increase sudden death risk. The aim of the proje...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2009
    • •
  • 9 152 tis. Kč
    • •
  • 8 290 tis. Kč
    • •
  • MZ
Project

Modeling activation of human calcium release-activated channels. (GJ19-20728Y)

Calcium ions are primarily used by cells as messenger. From cell birth in calcium ion levels onset apoptosis mechanisms. CRAC is a protein involved of the calcium stores upon depletion. CRAC is the combination of one channel

Physical chemistry

  • 2019 - 2021
    • •
  • 3 479 tis. Kč
    • •
  • 3 479 tis. Kč
    • •
  • GA ČR
Project

Activation and regulation mechanisms of nociceptor-specific transient receptor potential channels physiological role in acute and chronic pain (GA305/09/0081)

a subclass of transduction ion channels that exhibit an exquisite specificity. These channels are specifically expressed in primary nociceptive neurons and work in concert ofthermosensitive TRPV1-4, TRPA1 and TRPM8 cha...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2013
    • •
  • 6 559 tis. Kč
    • •
  • 6 559 tis. Kč
    • •
  • GA ČR
Project

Ion Beam Analysis study of crystalline structures (KJB100480601)

Main aim of the project is the characterization of the structures based on LiTaO3, single crystal SrTiO3, BaTiO3 and KTaO3 doped Pb, Mg materials using ion beam be determined by the innovative analytical technique (RBS-channeling) a...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2006 - 2008
    • •
  • 793 tis. Kč
    • •
  • 793 tis. Kč
    • •
  • AV ČR
Project

Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)

The aim of this study is to identify the major ion channels or transporters in vivo. The effect of specific ion channel or transporter inhibitors on cell volume will be correlated with changes in intracellular Na+,...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • GA ČR
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