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3 272 (0,107s) •

Project

Surpassing the Diffraction Limit in Label-Free Microscopy (LL2409)

In this project, I introduce the next generation of super-resolution microscopy relying on direct and label-free imaging of single-biomolecule fluctuations at high-speed to offer a complementary insight into the complex dyn...

Optics (including laser optics and quantum optics)

  • 2024 - 2026
    • •
  • 24 416 tis. Kč
    • •
  • 24 416 tis. Kč
    • •
  • MŠMT
Project

Machine-learning assisted tomographic phase imaging flow cytometry (MAGICY) (GN25-17712I)

label-free tomographic phase imaging flow cytometry for the examination of livingInvasive staining processes of living cells have motivated researchers to develop novel label-free strategies for their non...

Optics (including laser optics and quantum optics)

  • 2025 - 2027
    • •
  • 4 917 tis. Kč
    • •
  • 4 917 tis. Kč
    • •
  • GA ČR
Project

Life of a single biomolecule in a motion picture (GA22-18203S)

limitations and to image individual proteins in free motion without any labelNumerous biomolecules and their interactions possess physiologically relevant heterogeneities that can be unravelled only by means of single-mole...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 6 840 tis. Kč
    • •
  • 6 716 tis. Kč
    • •
  • GA ČR
Project

Metal-nanopartcials based multilabeling for bioimaging (GA17-12774S)

multiplex imaging of several molecules in tissues. The concept is based on the interaction of antibody labelled with metal-based nanoparticle with its antigen. The metal-based nanoparticle will be imaged by means of laser ...

CB - Analytická chemie, separace

  • 2017 - 2021
    • •
  • 6 136 tis. Kč
    • •
  • 6 055 tis. Kč
    • •
  • GA ČR
Project

Label-free super-resolution microscopy based on single-protein fluctuations to study the assembly of tau protein envelopes (GA23-07703S)

label-free method based on direct detection of single-protein fluctuation using fluorescence principle hinders imaging highly dynamical or complex systems. This blind spot......

Cell biology

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 981 tis. Kč
    • •
  • GA ČR
Project

Novel Metal-Free Contrast Agents for 1H Magnetic Resonance and Optical Imaging (NW24-08-00144)

the incorporation of drug molecules, targeting agents, and additional imaging labels, openingThis research proposal aims to design and evaluate novel, metal-free contrast agents for Magnetic Resonance Imaging (MRI...

Medicinal chemistry

  • 2024 - 2027
    • •
  • 13 318 tis. Kč
    • •
  • 13 318 tis. Kč
    • •
  • MZ
Project

Boosting incoherent quantitative phase imaging by implementing 3D-image reconstruction (GA24-12283S)

techniques, therefore enables label-free imaging and biomass-distribution measurementHolographic incoherent-source quantitative phase imaging (hiQPI) is a modern imaging technique with a potential to beco...

Optics (including laser optics and quantum optics)

  • 2024 - 2026
    • •
  • 5 860 tis. Kč
    • •
  • 5 658 tis. Kč
    • •
  • GA ČR
Project

Development of immunoassay RIA kits based on steroid histamine derivatives (FV20061)

of free testosterone per labeling by radioactive iodine 125I 3. (2019). - Aldosterone for determination of free testosterone, progesterone, aldosterone and cortisol. The main aim of aldosterone per labeling by rad...

CE - Biochemie

  • 2017 - 2020
    • •
  • 12 874 tis. Kč
    • •
  • 7 359 tis. Kč
    • •
  • MPO
Project

Optical imaging of single protein dynamics (LL1602)

This project aims at a fundamentally new method capable of detecting and tracking the conformational dynamics of proteins at a single-molecular level, at their native time scales, and ultimately without the use of any labels. Understanding t...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2021
    • •
  • 40 738 tis. Kč
    • •
  • 40 738 tis. Kč
    • •
  • MŠMT
Project

Nanoparticle probes for mass spectrometry imaging (GA21-12262S)

The proposal extends the concept of single-particle mass spectrometry imaging will be used for nanoparticle imaging in sections of 3D cell aggregates and dried droplet. Prospective applications of the methods include multiparameter...

Analytical chemistry

  • 2021 - 2023
    • •
  • 7 583 tis. Kč
    • •
  • 7 583 tis. Kč
    • •
  • GA ČR
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