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12 063 (0,17s) •

Project

Production of taxol ant its analogues by Taxus sp. cells cultivated in vitro (IAA5055601)

. The project is focused not only on the direct production of taxol and its analogues brevifolia, is at present one of the most promissing natural substances, negatively affected by its limited natural sources. Tax...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 2 091 tis. Kč
    • •
  • 1 043 tis. Kč
    • •
  • AV ČR
Project

Natural Lactones and Lactams Towards Diverse Biological Activities through Purposeful Synthetic Manipulations (GA15-07332S)

Based on their ability to selectively inhibit or activate proteins with strategic functions in living organisms, natural products have again started to play and screening of small libraries of purposefully designed analogues

CC - Organická chemie

  • 2015 - 2017
    • •
  • 4 908 tis. Kč
    • •
  • 4 908 tis. Kč
    • •
  • GA ČR
Project

Brassinolide Analogues with Increased Metabolic Stability (IAA400550609)

synthetic and natural analogues is their low metabolic stability in plant tissuesNatural plant hormone brassinolide has high plant-growth supporting activity in greenhouse as well as field tests. The project will afford ne...

CC - Organická chemie

  • 2006 - 2010
    • •
  • 2 676 tis. Kč
    • •
  • 2 676 tis. Kč
    • •
  • AV ČR
Project

Structure-activity relationship (SAR) study of immunosuppressive effects of pyrimidine analogues (GAP303/12/0172)

pyrimidine analogues. Their immunosuppressive effects will be evaluated by means of the natural pyrimidine structure, all in combination with a number of specific of the compounds with stimulation and production of cytokin...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 15 179 tis. Kč
    • •
  • 15 179 tis. Kč
    • •
  • GA ČR
Project

8-Substituted Analogues of Cytokinins - Utilization of their Potential New Quality in Plant Research (KJB6137301)

8-Substituted analogues of natural cytokinins with small substituents in position 8 will be prepared and their structure-activity reationship compared in three bioassays. Analogues with and 8-alkylamino chain will be couple...

EF - Botanika

  • 2003 - 2005
    • •
  • 3 653 tis. Kč
    • •
  • 978 tis. Kč
    • •
  • AV ČR
Project

Preparation of taxol and its analoques. (PZ-CH/33)

Development a procedure for small-scale production of taxanol its analogues. Preparation of a new taxol analogues....

FR - Farmakologie a lékárnická chemie

  • 1997 - 2001
    • •
  • 15 216 tis. Kč
    • •
  • 7 716 tis. Kč
    • •
  • MH
Project

Lactone-based natural products useful leads in the development of new antifungals and antineoplastics (GA203/07/1302)

The virtue of using natural products as prototypes of pharmaceutical agents, the production of small, intelligently designed natural product-based series of compounds may ongoingresearch on small bioactive...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 2 421 tis. Kč
    • •
  • 2 421 tis. Kč
    • •
  • GA ČR
Project

Heterodendralene-based approach to isocoumarins and isolycoricidine (GA22-19209S)

of biologically interesting natural products. The limited flexibility of the heterodendralenes natural isocoumarins with potential antiinfective and antidiabetic activity, and potentially cytotoxic analogues of ly...

Organic chemistry

  • 2022 - 2024
    • •
  • 6 489 tis. Kč
    • •
  • 6 489 tis. Kč
    • •
  • GA ČR
Project

Study of production of taxol and its analogues by plant tissue cultures (IAA555114)

EE - Mikrobiologie, virologie

  • 1993 - 1995
    • •
  • 150 tis. Kč
    • •
  • 300 tis. Kč
    • •
  • AV ČR
Project

Application of Pd-mediated processes in drug synthesis development of novel antifungals and cytostatics based on natural lactones (GA203/04/2134)

Natural products possessing interesting biological properties have often served structural motiff is also present in other natural furanones, andunsaturated d-lactone moiety is the main structural feature of some antifungal...

CC - Organická chemie

  • 2004 - 2006
    • •
  • 1 381 tis. Kč
    • •
  • 1 381 tis. Kč
    • •
  • GA ČR
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