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12 (0,094s) •

Project

How systematic changes to the membrane proteome and cardiolipin drive mitochondrial cristae development (GA23-07674S)

Cristae are self-contained subcompartments derived from the mitochondrial inner respiration. Mysteriously, cristae assume many shapes in eukaryotes to perform OXPHOS, perhaps due to different crista development mechanisms. ...

Cell biology

  • 2023 - 2025
    • •
  • 8 576 tis. Kč
    • •
  • 8 576 tis. Kč
    • •
  • GA ČR
Project

Dissection of the integrated factors involved in mitochondrial cristae formation (GA20-23513S)

Cristae are mitochondrial inner membrane (IM) protrusions jutting by an eponymously-named complex. Cristae dynamism is exemplified during the pathogenic protist Trypanosoma brucei’s life cycle. Here, a cristae-lacking stage...

Cell biology

  • 2020 - 2023
    • •
  • 7 619 tis. Kč
    • •
  • 7 619 tis. Kč
    • •
  • GA ČR
Project

Fluorescence nanoscopy of pancreatic beta cells (GA23-05798S)

3D nanoscopy has not yet assessed dynamics of mitochondrial (mt) cristae, morphology of nucleoids (mtDNA & protein complexes) relatively to cristae upon mtDNA replication. Hence, we’ll develop nanoscopy of mt cristae dynami...

Endocrinology and metabolism (including diabetes, hormones)

  • 2023 - 2025
    • •
  • 7 599 tis. Kč
    • •
  • 7 599 tis. Kč
    • •
  • GA ČR
Project

The role of mitochondrial ATP-sensitive K+ channel and redox status in mitochondrial cristae morphology changes monitored by nanoscopy (GA25-15495S)

Mitochondrial cristae are self-sufficient bioenergetic subunits, and there is still a significant gap in knowledge about how the cristae morphology is regulated. We will investigate the hypothesis of osmotic regulation of mitochondr...

Biophysics

  • 2025 - 2027
    • •
  • 9 999 tis. Kč
    • •
  • 9 917 tis. Kč
    • •
  • GA ČR
Project

The role of ATP synthase structure in the biogenesis and bioenergetics of the unique Trypanosoma brucei mitochondrion (GA18-17529S)

Mitochondrial (mt) cristae are inner membrane convolutions where protein factories responsible for bioenergy conversion reside. The cristae exhibit an extremely - the presence of ATP synthase dimer rows at the crista ridges...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 6 731 tis. Kč
    • •
  • 6 512 tis. Kč
    • •
  • GA ČR
Project

Sirtuin-3 participation in regulation of mitochondrial morphology (GA16-04788S)

We'll continue in our world priority revealing of hypoxic mitochondrial cristae thickening contrasting to cristae thinning during glucose-stimulated insulin secretion dimers or such GSIS-accompanied dimerization determining cris...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 6 435 tis. Kč
    • •
  • 5 940 tis. Kč
    • •
  • GA ČR
Project

Evolution and biogenesis of mitochondrial cristae the ancient MICOS complex’s composition and function in the diverged model Trypanosoma brucei (GA17-24036S)

of the inner membrane (IM) that makes cristae, structures needed for mitochondrial (mt now commencing. A protein complex responsible for cristae protrusions from the IM at cristae junctions (CJs) is called the mt contact s...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 5 448 tis. Kč
    • •
  • 5 349 tis. Kč
    • •
  • GA ČR
Project

Supramolecular organization of mitochondrial ATP synthase in metabolic regulations (GA17-08565S)

Oligomers of mitochondrial ATP-synthase form cristae edges and determine cristae morphology in relation to metabolism. This relationship will be elucidated upregulated metabolism, we will elucidate previously observed cristae

EA - Morfologické obory a cytologie

  • 2017 - 2019
    • •
  • 6 594 tis. Kč
    • •
  • 6 462 tis. Kč
    • •
  • GA ČR
Project

Project CRISTA/space shuttle (IAA3042502)

DG - Vědy o atmosféře, meteorologie

  • 1995 - 1997
    • •
  • 478 tis. Kč
    • •
  • 478 tis. Kč
    • •
  • AV ČR
Project

Dynamics of mitochondrial cristae ultramorphology upon insulin secretion in pancreatic beta cells and metabolic deprivation in cancer cells (GA21-01205S)

Related to our discovery of cristae narrowing upon glucose-stimulated insulin secretion (GSIS) in pancreatic beta cells and reversal of metabolic deprivation of cancer cells, we’ll identify mechanism of cristae narrowing, 3D-redistr...

Physiology (including cytology)

  • 2021 - 2024
    • •
  • 9 588 tis. Kč
    • •
  • 9 543 tis. Kč
    • •
  • GA ČR
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