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9 700 (0,138s) •

Project

Pushing the limits of the cellular plasticity in the intestinal epithelium by altering the cellular fates of differentiated cells (GA25-17207S)

The cellular plasticity connected to re-activated embryonic gene expression allows the intestinal epithelial cells to face epithelial damage. On the other hand, de-differentiation and cellular plasticity are required for ca...

Cell biology

  • 2025 - 2027
    • •
  • 11 806 tis. Kč
    • •
  • 11 806 tis. Kč
    • •
  • GA ČR
Project

Activation of Chk1 and Chk2 kinases in response to stress in mouse embryonic stem cells. (NR9508)

Study of activation of Chk1 and Chk2 kinases in G1 checkpoint in mouse embryonic stem cells. Characterization of kinases involved in regulation of G1 checkpoint in mouse embryonic stem cells. Study of influence of an ac...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 2 774 tis. Kč
    • •
  • 2 771 tis. Kč
    • •
  • MZ
Project

Transformations of the gastrointestinal stem cell niche during the development and regeneration (GA21-26025S)

Recent data suggest re-acquiring of embryonic features during the progression of colon cancer and intestinal regeneration. Additionally, intestinal epithelial stem cells change their signature from embryonic to adult one du...

Cell biology

  • 2021 - 2023
    • •
  • 8 487 tis. Kč
    • •
  • 8 487 tis. Kč
    • •
  • GA ČR
Project

Embryonics of pre-implantation mammalian development (GA523/06/1226)

Pre-implantation development of mammals is distinguished by a series of critical events on the molecular level, from which the embryonic gene activation early embryonic development. The most knowledge about the genome a...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2006 - 2008
    • •
  • 2 637 tis. Kč
    • •
  • 2 637 tis. Kč
    • •
  • GA ČR
Project

Maternal protein degradation and its impact on the development quality of mammalian preimplantation embryo (GA23-05108S)

embryonic genome activation (EGA) when transcription from embryonic genome starts, whose degradation is necessary for the activation of the embryonic genome in lowerThe early embryonic developmen...

Developmental biology

  • 2023 - 2025
    • •
  • 8 123 tis. Kč
    • •
  • 8 123 tis. Kč
    • •
  • GA ČR
Project

Regulation of transcriptional activity during preimplantation development of mammals (GA204/02/1145)

oogenetic to zygotic genomic control (zygotic gene activation - ZGA). ZGA includes in the early embryonic development of bovines. The aim of this project is to find out, howis synthesis of these mRNAs controlled during the embr...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 300 tis. Kč
    • •
  • 2 367 tis. Kč
    • •
  • GA ČR
Project

Proliferation structure of the embryonic kidney as a target of action of adverse enviromental factors (GA304/04/0972)

Developmental disturbance of the embryonic kidney (the mesonephros) may to te axial embryonic structures and starts functioning immediately after the onset of embryonic blood circulation, its developmental failure may influ...

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 1 489 tis. Kč
    • •
  • 1 489 tis. Kč
    • •
  • GA ČR
Project

Zygotic activation of cyclin genes with accent to cyclin A1 in the mouse (GA523/00/0780)

The proposed project concentrates on mammalian early embryonic development, and, especially on analysis of zygotic activation of cyclin genes (i.e. expression of cyclins from embryonal genome). The reliable and simple metho...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2000 - 2002
    • •
  • 1 782 tis. Kč
    • •
  • 1 504 tis. Kč
    • •
  • GA ČR
Project

CDC25 phosphatases ? key regulator of mammalian oocytec maturation and early embryonic development (ME08030)

. CDC25A/B/C dual phosphatases are activators of cyclin-dependent kinases (CDKs activation during resumption of meiosis. CDC25B -/- oocytes are unable to resume meiosis and form a metaphase spindle. CDC25A -/- mice are embryonic...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 3 328 tis. Kč
    • •
  • 1 600 tis. Kč
    • •
  • MŠMT
Project

Compensatory mechanisms and alternative signalling pathways in embryonal apoptosis (IAA600450904)

morphogenesis. Apoptosis as the best known way of physiological cell death can be activated via membrane receptors or intrinsic pathways. Activation of caspase machinery be activated, moreover, compensatory mechanisms amon...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 2 970 tis. Kč
    • •
  • 2 970 tis. Kč
    • •
  • AV ČR
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