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4 126 (0,238s) •

Project

The electrochemical detection of 3-methylhistidine in urine as a indicator of degradation of the skeletal muscle proteins (GP203/03/D094)

Concentration of 3-methylhistidine in biological fluids such as urine, plasma, tissue fluids, indicates the extent of degradation of the skeletal muscle proteins. For the determination of 3-methylhistidine. a novel...

CB - Analytická chemie, separace

  • 2003 - 2006
    • •
  • 731 tis. Kč
    • •
  • 731 tis. Kč
    • •
  • GA ČR
Project

Determination of pure muscle proteins by direct method (QK21020199)

of the determination of 3-methylhistidine and the NIR method. Changes in protein (proteome) content...

Food and beverages

  • 2021 - 2023
    • •
  • 6 207 tis. Kč
    • •
  • 6 207 tis. Kč
    • •
  • MZe
Project

Lean meat content is the best quality parameter of meat products. (EP9179)

typical component (for structural formula see Figure 1) of meat proteins, e.g., 3-methylhistidine (3-MeHis; [S]-1-methylimidazole-4-alanine; t-methyl-L-histidine), Ne-methyllysine and creatinine. Especially 3-MeHi...

GM - Potravinářství

  • 1999 - 2002
    • •
  • 760 tis. Kč
    • •
  • 550 tis. Kč
    • •
  • MZe
Project

Role of the 14-3-3 protein in the regulation of phosducin function (GAP305/11/0708)

The main goal is to study the structural basis for the 14-3-3 protein-dependent and Ser73 and the binding to the regulatory 14-3-3 protein. The detailed mechanism of the 14-3-3 protein-dependent i...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 6 340 tis. Kč
    • •
  • 6 340 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction between 14-3-3 protein and regulator of G protein signaling RGS3. (IAA501110801)

The main goal of this project is to understand the structural basis of 14-3-3 protein?dependent regulation of function of RGS3 protein. 14-3-3 proteins known to be 14-3-3 binding partners. The rol...

BO - Biofyzika

  • 2008 - 2012
    • •
  • 5 095 tis. Kč
    • •
  • 5 095 tis. Kč
    • •
  • AV ČR
Project

Molecular basis of regulation of cyclin-dependent kinase CDK16 by 14-3-3 proteins (GA25-15222S)

to a complex of phosphorylated cyclin Y (pCCNY) with 14-3-3 proteins. Thus, CDK16. Additionally, CDK16 also directly interacts with 14-3-3 proteins, although the function mechanism of CDK16 regulation and the role...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 12 110 tis. Kč
    • •
  • 12 001 tis. Kč
    • •
  • GA ČR
Project

Role of the phosphorylation and the 14-3-3 protein binding in the regulation of signaling complexes function (GA204/06/0565)

The overall goal of this project is to understand the structural basis of 14-3-3 protein-dependent regulation of function of two biologically important signaling complexes: 14-3-3 protein/forkhead transcription fac...

BO - Biofyzika

  • 2006 - 2008
    • •
  • 2 802 tis. Kč
    • •
  • 2 802 tis. Kč
    • •
  • GA ČR
Project

Study of the molecular mechanism of 14-3-3 isoform binding specificity (KJB5011308)

The 14-3-3 proteins are a family of regulatory molecules, which specifically, the 14-3-3 proteins play key regulatory roles in signal transduction, cell cycle of 14-3-3 isoform binding specificity...

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 578 tis. Kč
    • •
  • 2 004 tis. Kč
    • •
  • AV ČR
Project

14-3-3 protein dependent regulation of caspase-2 (GA17-00726S)

. Phosphorylated procaspase-2 (proC2) binds to the 14-3-3 protein and this interaction blocks mechanism we propose to: i) verify sites responsible for the 14-3-3 protein binding to proC2, ii) perform biophysical ch...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 8 069 tis. Kč
    • •
  • 7 580 tis. Kč
    • •
  • GA ČR
Project

Study of the role of 14-3-3 proteins in the regulation of Forkhead transcription factor AFX activity (GA204/03/0714)

The 14-3-3 proteins have attracted substantial attention over the past few years because of their diverse biological effects. In particular, 14-3-3 proteins cycle control,and nutrient-sensing pathways. 14-3

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 623 tis. Kč
    • •
  • 2 623 tis. Kč
    • •
  • GA ČR
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