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132 (0,146s) •

Project

Optimising molecular cytogenetic and molecular genetic diagnostics of chromosomal aberrations in patients with mental retardation (NR9457)

cytogenetic and other methods according to dysmorphic traits. Detection of subtelomeric rearrangements, microdeletions, specification of supranumerary marker chromosomes. Detailed......

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 7 098 tis. Kč
    • •
  • 7 032 tis. Kč
    • •
  • MZ
Project

Molecular basis of congenital microcephaly - using molecular genetics and molecular cytogenetic methods for detection of etiology of different types of microcephaly and evaluation of clinical and genetic prognosis (NR7916)

Detection of structural submicroscopic chromosomal aberrations and gene mutations in MCPH genes and genes reponsible for syndromic congenital microcephalies (NBS1, MSS) in a cohort of patients with congenital microcephaly. Estimation of frequency of ...

EB - Genetika a molekulární biologie

  • 2004 - 2007
    • •
  • 2 975 tis. Kč
    • •
  • 2 541 tis. Kč
    • •
  • MZ
Project

Tandem Sigmatropic Rearrangement/Radical Reactions - A New Productive Alliance in Organic Chemistry (GA16-18513S)

rearrangements and radical reactions. The critical rearrangement steps will be on one hand anionic [3,3]-sigmatropic rearrangements such as the Cope or Carroll rearrangements, and on the other hand different types...

CC - Organická chemie

  • 2016 - 2020
    • •
  • 3 870 tis. Kč
    • •
  • 2 646 tis. Kč
    • •
  • GA ČR
Project

A New Carbanion Rearrangement and Its Application in Organic Synthesis (GAP207/11/1598)

We discovereda new carbanion rearrangement for silylalkyl sulfones. With the current projectthe factors determining the course of the rearrangement must be uncovered. The applicability of this new rearrangement will be inve...

CC - Organická chemie

  • 2011 - 2013
    • •
  • 3 405 tis. Kč
    • •
  • 3 405 tis. Kč
    • •
  • GA ČR
Project

The study of pathogenesis of acute leukemias (AL) with 11q23 chromosomal rearrangement (GA301/01/0489)

The 11q23 chromosomal rearrangement, involving transcription factor MLL, has been implicated in an variety of acute leukemias (AL). The AL with MLL rearrangement are either de-novo or secondary (therapy related) and are associated w...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 604 tis. Kč
    • •
  • 4 604 tis. Kč
    • •
  • GA ČR
Project

What cells are responsible for unselected B cell repertoire in the porcine thymus? (GA16-09296S)

of HC rearrangement as it might be expected. Our preliminary results show that complete HC rearrangement clearly occurs in the thymus. This observation indicates that the inhibition of B cell development in the thymus occurs after ...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2016 - 2020
    • •
  • 6 036 tis. Kč
    • •
  • 6 036 tis. Kč
    • •
  • GA ČR
Project

Different order of immunoglobulin light chain rearrangement in swine (GA19-01504S)

chains (IgH) gene rearrangement during development of B cells in swine occur during reversed order of Ig rearrangement. However, these assumptions before and after IgH rearrangement, and the role of pre-B receptor genes λ5...

Veterinary science

  • 2019 - 2021
    • •
  • 8 309 tis. Kč
    • •
  • 8 309 tis. Kč
    • •
  • GA ČR
Project

Chromosomal rearrangements with breakpoints in T cell receptor genes (GAP502/12/1966)

T cell receptor genes (TR) are rearranged during maturation of T cells by site of chromosomes. Rearrangements of TR genes with oncogenes are recurrent in several T cell malignancies. It has been suggested that the number of trans-

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 855 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Project

Study of etiological significance of rare sequence variants and intragenic rearrangements in BRCA1&2 genes in the patients with hereditary breast and ovarian cancer (NR8213)

Probability estimation of the causality of rare sequence variants detected in BRCA1 and BRCA2 genes in the patients with hereditary breast and/or ovarian cancer syndrome will be estimated. Investigation of intragenic rearrangements in BRCA1 ...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 953 tis. Kč
    • •
  • 3 671 tis. Kč
    • •
  • MZ
Project

Clinical application of molecular diagnostic approaches of gene rearrangements in malignant tumors in childhood (NM6)

Morphological diagnostics of sarkomas and lymphomas is laborious.Detection of gene rearrangements improves the tumor diagnosis,determines bone marrow dissemination and minimal residual disease. The purpose is to improve prognosis of patients...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 2 542 tis. Kč
    • •
  • 2 542 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 132