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3 074 (0,117s) •

Project

Role of protein phosphatases in regulation of microtubule organization in mast cells (GA16-23702S)

nucleation, interacts with proteins transiently phosphorylated during mast cell activation, and inhibition of tyrosine phosphatases affects microtubule organization. Very recently we have identified tyrosine p...

EC - Imunologie

  • 2016 - 2018
    • •
  • 5 458 tis. Kč
    • •
  • 5 400 tis. Kč
    • •
  • GA ČR
Project

Role of protein tyrosine kinases and phosphatases in the regulation of microtubule nucleation during mast cell activation (GA21-30281S)

. Stimulation of cells results in the activation of protein tyrosine kinases, calcium influx stimulates MT formation and that GIT adaptor protein interacts with γ-tubulin and regulates MT nucleation. A corresponding signali...

Cell biology

  • 2021 - 2023
    • •
  • 7 800 tis. Kč
    • •
  • 7 800 tis. Kč
    • •
  • GA ČR
Project

Nonreceptor tyrosine phosphatases in antigen activated mast cells (GA204/03/0594)

mediators of allergic reactions. The first step in this process is tyrosine phosphorylationofFceRI subunits by Src family kinase Lyn. Other protein tyrosine kinases (PTKs of tyrosine phosphorylation of signaling m...

EC - Imunologie

  • 2003 - 2005
    • •
  • 1 998 tis. Kč
    • •
  • 1 998 tis. Kč
    • •
  • GA ČR
Project

Protein tyrosine phosphatases in regulation of the immune system of diabetic patients (GAP301/12/1686)

underestimated regulators of immune cell signal transduction are tyrosine phosphatases. We, and which will allow tests of pharmacological modulation of the selected phosphatase......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2014
    • •
  • 4 983 tis. Kč
    • •
  • 4 983 tis. Kč
    • •
  • GA ČR
Project

New diagnostic and predictive markers of diabetes mellitus (NT13663)

characterisation of new markers (tyrosine phosphatases) useful for the diagnostics treatment. We plan to perform pharmacologic modulation of selected phosphatase......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2014
    • •
  • 4 202 tis. Kč
    • •
  • 4 202 tis. Kč
    • •
  • MZ
Project

Posttranslational phosphorylations of proteins and peptides (GA203/98/P201)

in molecules of proteins. (2) Observation of the activity of acid phosphatases in relationPhosphorylation of proteins is posttranslational modification, which of serine, tyrosine or threonine. Modification by phos...

CE - Biochemie

  • 1998 - 2001
    • •
  • 802 tis. Kč
    • •
  • 712 tis. Kč
    • •
  • GA ČR
Project

Center of Molecular and Cellular Immunology (1M0506)

Elucidate immune functions of selected signaling molecules(adaptor proteins PAG, NTAL, LIME, nonreceptor protein-tyrosine and lipid phosphatases) and defects of their functions in some diseases. Identify, clone and...

EC - Imunologie

  • 2005 - 2011
    • •
  • 242 918 tis. Kč
    • •
  • 215 618 tis. Kč
    • •
  • MŠMT
Project

Supramolecular organization of surface receptors of the cells of immune system (GA204/96/0674)

the receptor tyrosine phosphatase CD45RA and a so far unidentified phosphoprotein. Th emain aim of this project will be to identify the protein and lipidic components glzcoszlphosphosphatidylinositol (GPI) and protein<...

CE - Biochemie

  • 1996 - 1998
    • •
  • 2 362 tis. Kč
    • •
  • 1 632 tis. Kč
    • •
  • GA ČR
Project

Influence of tyrosine oxidation on structure of neurodegenerative proteins (GA17-00121S)

of tyrosine in proteins such as 3-chloro-L-tyrosine, 3-nitro-L-tyrosine, and 3,3Structural changes of neurodegenerative proteins caused by oxidative stress. Since the secondary structure of mutated p...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 5 864 tis. Kč
    • •
  • 5 669 tis. Kč
    • •
  • GA ČR
Project

Involvement of phosphatases on CDK regulation in G2/M transition of Chlamydomonas reinhardtii cell cycle. (GPP501/10/P258)

Phosphorylation of proteins by kinases and phosphatases plays a key regulatory phosphatase activity activates the CDK-cyclin complex inhibited by Wee1 kinase. While tauri no CDC25 homolog was identified in plant. Three pred...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 584 tis. Kč
    • •
  • 1 584 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 3 074