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9 (0,083s) •

Project

Fluorescence nanoscopy of pancreatic beta cells (GA23-05798S)

3D nanoscopy has not yet assessed dynamics of mitochondrial (mt) cristae, morphology of nucleoids (mtDNA & protein complexes) relatively to cristae upon mtDNA replication. Hence, we’ll develop nanoscopy of mt cristae dynamics in pan...

Endocrinology and metabolism (including diabetes, hormones)

  • 2023 - 2025
    • •
  • 7 599 tis. Kč
    • •
  • 7 599 tis. Kč
    • •
  • GA ČR
Project

The role of mitochondrial ATP-sensitive K+ channel and redox status in mitochondrial cristae morphology changes monitored by nanoscopy (GA25-15495S)

will develop fluorescence nanoscopy (3D stochastic and STED) to visualize cristae on molecular physiology. Advanced nanoscopy, biophysics and molecular biology techniques......

Biophysics

  • 2025 - 2027
    • •
  • 9 999 tis. Kč
    • •
  • 9 917 tis. Kč
    • •
  • GA ČR
Project

The role of cell wall biomechanics in the control of Arabidopsis root growth and development (GA22-17501S)

, super-resolution nanoscopy, and mathematical modelling to elucidate the role...

Plant sciences, botany

  • 2022 - 2024
    • •
  • 5 912 tis. Kč
    • •
  • 5 912 tis. Kč
    • •
  • GA ČR
Project

Observing single-molecule pirouettes (GA25-16414S)

The ability to measure the dynamics of biological processes at the single-molecule level is essential to unraveling complex living systems. In processes such as enzymatic unwinding of DNA, the displacements of the involved molecules are subtle in com...

Optics (including laser optics and quantum optics)

  • 2025 - 2028
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial membrane contact sites with the nuclear envelope and nucleoids analysed by FIB/SEM and fluorescence nanoscopy (GA22-02203S)

Membrane contact sites (MCSs) represent key hubs of communication between cellular organelles and tremendous efforts have been made in recent years to understand their role. In this project, we will specifically focus on yet uncharacterized MCSs betw...

Anatomy and morphology (plant science to be 1.6)

  • 2022 - 2025
    • •
  • 7 871 tis. Kč
    • •
  • 7 823 tis. Kč
    • •
  • GA ČR
Project

Megahertz Imaging of Microtubule Dynamics by Interferometric Scattering Microscopy (GA22-11753S)

Microtubules are cytoskeletal polymers composed of tubulin subunits that reversibly assemble into hollow tubes, alternating between periods of assembly and disassembly. During microtubule disassembly, electron micrographs suggest structural transitio...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • GA ČR
Project

New insights into cooperation of micro- and nano-scale elementary structural chromatin units in decision-making on DNA damage repair pathway (NANOREP) (GC20-04109J)

Based on the novel strategy we proposed, the project attempts to bring the answers on a long-time unresolved fundamental biological ‘hen and egg’ question, whether it is the pre-existing chromatin architecture that determines initiation of specific c...

Cell biology

  • 2020 - 2022
    • •
  • 9 816 tis. Kč
    • •
  • 9 786 tis. Kč
    • •
  • GA ČR
Project

Dynamics of mitochondrial cristae ultramorphology upon insulin secretion in pancreatic beta cells and metabolic deprivation in cancer cells (GA21-01205S)

will be combined with up-to-date 3D nanoscopy, in order to elucidate the increase ATP synthesis...

Physiology (including cytology)

  • 2021 - 2024
    • •
  • 9 588 tis. Kč
    • •
  • 9 543 tis. Kč
    • •
  • GA ČR
Project

Resonant waveguide-graphene plasmon coupling for improved THz and MIR light control (8J24FR002)

of THz and MIR nanoscopy. A strong engagement of PhD students and junior scientists...

Optics (including laser optics and quantum optics)

  • 2024 - 2025
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
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