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1 207 (0,104s) •

Project

Circadian regulation of kynurenine pathway enzymes in rat brain and peripheral organs (GA23-07184S)

with the disruption of the kynurenine pathway. Our preliminary results show the circadian rhythms of kynurenine enzyme expression and the alteration of their expression profiles in animals of circadian regulation of ky...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2023 - 2025
    • •
  • 7 392 tis. Kč
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  • 7 392 tis. Kč
    • •
  • GA ČR
Project

Tissue trauma and postoperative stress in patients with surgically treated early endometrial cancer stages (NT13566)

, Kynurenin, Citrulin, retinol and alpha-tocopheryl will be evaluated. Neopterin, kynurenin,retinol, alpha-tocopherol, citrulin as well as robotic surgery have not been......

FK - Gynekologie a porodnictví

  • 2012 - 2015
    • •
  • 6 142 tis. Kč
    • •
  • 6 142 tis. Kč
    • •
  • MZ
Project

Kynurenines and their role in the inflammatory response and pathophysiology of cerebral vasospasms following the aneurysmal subarachnoid hemorrhage (NW25-04-00246)

metabolism recently gain a lot of attention as the alteration in metabolic pathway occur will be used to study the effect of the kynurenine monooxygenase inhibitor, which blocks......

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 13 891 tis. Kč
    • •
  • 13 891 tis. Kč
    • •
  • MZ
Project

The influence of immune system dysregulation and latent toxoplasmosis on brain morphology in schizophrenia animal models and a prospective volumetric study in patients (NT13843)

and metabolites of kyunurenine pathway, glutamatergic and dopaminergic activity...

FL - Psychiatrie, sexuologie

  • 2012 - 2015
    • •
  • 8 950 tis. Kč
    • •
  • 8 950 tis. Kč
    • •
  • MZ
Project

Clinical and neurobiological predictors of response to ketamine towards personalized treatment of depression (NV18-04-00260)

Depression is a debilitating disease with high lifetime prevalence. Despite the variety of available treatment options, three major problems remain unsolved: 1) the time lag before the onset of the effect of antidepressants, 2) the treatment resistan...

Psychiatry

  • 2018 - 2022
    • •
  • 10 048 tis. Kč
    • •
  • 10 048 tis. Kč
    • •
  • MZ
Project

Predictive factors of pathologic response to neoadjuvant chemotherapy in patients with HER-2 positive or triple negative breast carcinoma (NT13564)

Pathologic complete response is an indicator of long-term disease control after neoadjuvant chemotherapy in breast carcinoma. In our earlier study, patologic complete response was observed significantly more often in patients with tumors expressing H...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 9 695 tis. Kč
    • •
  • 9 695 tis. Kč
    • •
  • MZ
Project

Specific factors affecting the toxicity of hyperthermic intraperitoneal chemotherapy (NV18-03-00130)

biomarkers of immune response (neopterin, kynurenin, and tryptophan) and drug sensitivity...

Oncology

  • 2018 - 2021
    • •
  • 14 712 tis. Kč
    • •
  • 14 645 tis. Kč
    • •
  • MZ
Project

Development of chemical regulators of miRNA and RNAi pathways (GA13-29531S)

Here, we propose to use chemical biology to study miRNA and RNAi pathways. These pathways use small RNAs as sequence-specic guides for silencing gene expression. miRNAs of small molecules inhibiting or stimulating miRNA and RNAi

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 8 056 tis. Kč
    • •
  • 8 056 tis. Kč
    • •
  • GA ČR
Project

Establishing the signaling pathway associated with secondary injury, reactive oxygen species and inflammation in spinal cord injury and during its repair. (LTAUSA17120)

To study signalling pathways activated during spinal cord injury, particularly mTOR pathway in cells and in spinal cord tissue. To study inhibition of mTOR pathway using blocators of mTORC1 or mTORC2 complex. To study the e...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
    • •
  • 7 673 tis. Kč
    • •
  • 7 673 tis. Kč
    • •
  • MŠMT
Project

Placental tryptophan metabolism linking maternal inflammation and foetal neurodevelopmental disorders (NU20-01-00264)

. serotonin, melatonin, kynurenine, kynurenic acid and quinolinic acid). After release...

Endocrinology and metabolism (including diabetes, hormones)

  • 2020 - 2023
    • •
  • 9 740 tis. Kč
    • •
  • 9 665 tis. Kč
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  • MZ
  • 1 - 10 out of 1 207