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54 (0,117s) •

Project

BCR-ABL1-positive leukaemia - clinical and biological issues (NU21-03-00128)

of the disease, the BCR-ABL1-positive leukaemia has a specific position – BCR-ABL1 fusion on BCR-ABL1-positive ALL we described a new subtype of the disease and for its of different subtypes of <...

Hematology

  • 2021 - 2024
    • •
  • 13 383 tis. Kč
    • •
  • 13 383 tis. Kč
    • •
  • MZ
Project

Epigenetic, genetic and molecular factors required for mutagenesis of oncogene BCR-ABL1 during Ph+ cells treatment with tyrosine kinase inhibitor (GA18-18407S)

inhibition of BCR-ABL1 kinase activity by specific inhibitors (TKI), preferentially by imatinib in the first line treatment. Mutations in the BCR-ABL1 kinase domain represent, that development of TKI resistance by...

Biochemical research methods

  • 2018 - 2021
    • •
  • 10 249 tis. Kč
    • •
  • 9 100 tis. Kč
    • •
  • GA ČR
Project

Mutational screening of primitive cell populations in chronic myeloid leukemia BCR-ABL1 and beyond (NV17-30397A)

of BCR-ABL1 fusion gene and successfully treated by tyrosine kinase inhibitors (TKI, or by the cancer cell characteristics. Here the main reason are mutations in the BCR-ABL1 kinase domain, leading to TKI resistan...

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 8 058 tis. Kč
    • •
  • 8 058 tis. Kč
    • •
  • MZ
Project

Molecular detection of chronic myeloid leukemia using patient-specific BCR-ABL1 genomic fusions impact on effectiveness of treatment management (NV15-31540A)

) by quantification of patient-specific fusions of BCR-ABL1 gene at the DNA level with the aim monitoring of BCR-ABL1 transcript level. We will study the hypothesis that the level of BCR-ABL1-posi...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 9 672 tis. Kč
    • •
  • 9 672 tis. Kč
    • •
  • MZ
Project

Leukaemias with BCR ABL1 fusion - biological variability and optimal treatment strategies (NW25-03-00276)

BCR::ABL1-positive leukaemias, while widely studied, still pose significant work identified a novel "CML-like" subtype of BCR::ABL1-positive childhood acute elucidate the biological background and clinical implicat...

Hematology

  • 2025 - 2028
    • •
  • 17 146 tis. Kč
    • •
  • 17 146 tis. Kč
    • •
  • MZ
Project

Biology of BCR/ABL1-positive leukaemias (NV16-30186A)

BCR-ABL1 fusion is a hallmark of chronic myeloid leukaemia (CML) and is present of genomic fusion of BCR and ABL1 genes will help to establish the role of residual in lymphoid blast crisis. In the proposed project ...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 9 667 tis. Kč
    • •
  • 9 667 tis. Kč
    • •
  • MZ
Project

Genomic characterization of adult B-precursor acute lymphoblastic leukemia for prediction of treatment response to targeted therapy (NU22-03-00210)

sequencing technology, including BCR-ABL1-like ALL, ALL with DUX4, ZNF384, MEF2D in the induction phase for BCR-ABL1-negative ALL); 2) EWALL-INO Study with anti-CD22 immunoconjugate in the induction phase for ...

Hematology

  • 2022 - 2025
    • •
  • 14 637 tis. Kč
    • •
  • 14 637 tis. Kč
    • •
  • MZ
Project

Spectrum of NGS detected somatic mutations and their association with prognosis and outcome of adolescent and young adult patients with Ph-positive leukemias (NU21-07-00225)

landscape of somatic mutations outside the oncogene BCR-ABL1 in Ph positive leukemias...

Oncology

  • 2021 - 2024
    • •
  • 16 307 tis. Kč
    • •
  • 16 307 tis. Kč
    • •
  • MZ
Project

Role of BCR-ABL in CML cases with poor response to therapy but with low BCR-ABL transcript levels (NC7550)

In some of CML patients with poor response to treatment we have found low BCR-ABL transcript levels. We will study the role of BCR-ABL as well as BCR and ABL in order to find out whether CML mechanism may be independent of ...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 6 625 tis. Kč
    • •
  • 6 510 tis. Kč
    • •
  • MZ
Project

Utilization of centrosomal proteins for prognostication and vaccinotherapy of chronic myeloid leukemia (NT13862)

Search for prognostic markers of chronic myelogenous leukemia (CML) and development of DNA vaccines against this disease based on increased production of centrosomal proteins. Detection of HMMR/RHAMM, AURKA and ESPL1 mRNA level in blood cells and ant...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 9 681 tis. Kč
    • •
  • 9 681 tis. Kč
    • •
  • MZ
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