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36 (0,126s) •

Project

Expression of integrins during differentiation of Schwann cells and derivative structures of the peripheral nervous system of the rat (GA309/97/0107)

). Integrins involved in interactions between the cell and ECM have probably crucial of: i/ integrin expressions during glial cell differentiation in the PNS of prenatal and integrin expression; iii/ a function of integ...

EA - Morfologické obory a cytologie

  • 1997 - 1999
    • •
  • 2 016 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

Study of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin in brain cancer treatment (MEB020837)

The target of the project is investigation of synergisms of anticancer drug ellipticine and alfa5 beta1 integrin, which can be utilized in treatment of cancer such as brain tumors.......

CE - Biochemie

  • 2008 - 2009
    • •
  • 29 tis. Kč
    • •
  • 29 tis. Kč
    • •
  • MŠMT
Project

Artificial fibronectin-mimetic ligands for integrin-mediated cell adhesion to biomaterials (KJB400500904)

effective cell adhesion via integrin receptors only if the structures mediating interaction with integrins, e.g. RGDS and PHSRN peptide motifs, are attached in a particular distance, distributed in domains that make possible cluste...

CD - Makromolekulární chemie

  • 2009 - 2011
    • •
  • 2 471 tis. Kč
    • •
  • 2 471 tis. Kč
    • •
  • AV ČR
Project

The role of adhesion molecules in the regulation of TRAIL-induced apoptosis (KJB5052407)

molecules - integrins and their regulations partner for studiing influence of integrin and signailing pathways involved in integrin regulation of TRAIL-induced apoptosis selection and a role of integrins in its re...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 926 tis. Kč
    • •
  • 436 tis. Kč
    • •
  • AV ČR
Project

Preparation of surface nanoclusters of integrin ligands for control of cell adhesion (GPP207/10/P569)

Surfaces that mimic signaling properties of the extracellular matrix in vivo through the presentation of ligands of integrins (cell membrane receptors) can significantly contribute to the functionality of many biomedical systems including  c...

CD - Makromolekulární chemie

  • 2010 - 2014
    • •
  • 1 008 tis. Kč
    • •
  • 1 008 tis. Kč
    • •
  • GA ČR
Project

The Impact of Liver-specific Plectin Deficiency on Pathogenesis of Liver Diseases (GA15-23858S)

, consisting of the governing role of plectin for keratin networks and integrin clusters acid and plectin-controlled integrin signaling pathways. Using hepatocellular......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • GA ČR
Project

Reconstruction of the spinal cord sensory pathway using an integrin approach to axon regeneration. (GA24-11193S)

Spinal cord injury (SCI) causes impairment of sensory, motor and autonomic functions. Pilot experiments have demonstrated the possibility of regenerating sensory function after spinal cord injury by expressing alpha9 integrin and kindlin-1 i...

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 7 777 tis. Kč
    • •
  • 7 777 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction of adenylate cyclase toxin with the integrin receptor CD11b/CD18 (GP204/07/P105)

is mediated through the integrin receptor CD11b/CD18. Nevertheless, the mechanism the ACT-binding domain of the integrin receptor CD11b/CD18 using a set of genetically......

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 389 tis. Kč
    • •
  • 1 389 tis. Kč
    • •
  • GA ČR
Project

The effect of revealed receptor clusters on the regulation of adhesiveness and transmigration of white blood cells (GA305/01/1605)

Our investigation of L-selectin (CD62L) and beta 2 integrin (CDllb/CD18) adherence receptor distribution on the surface of leukocytes (polymorphonuclear neutrophils) by the 3-D optical scanning microscopy revealed their accumulation localize...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2001 - 2003
    • •
  • 1 541 tis. Kč
    • •
  • 551 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

in binding of ACT to the CD11b integrin receptor will be defined and the oligomeric...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
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