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16 756 (0,123s) •

Project

A New Approach to Diagnosis of Malignancy Based on Indirect Assay of "in vitro" Motility of Cells from Tumour Biopsies (IA75265)

FR - Farmakologie a lékárnická chemie

  • 1992 - 1994
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  • 0 tis. Kč
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  • 0 tis. Kč
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  • AV ČR
Project

The study of molecular mechanisms of anticancer and antiangiogenic activities of brassinosteroids (GP14-27669P)

immunofluorescence, western blotting and reporter assay; (iv) check in detail anticancer activities on various cancer and normal human cell lines (derived from leukemia, breast effects on cell cycle of these cells...

FR - Farmakologie a lékárnická chemie

  • 2014 - 2018
    • •
  • 2 376 tis. Kč
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  • 2 376 tis. Kč
    • •
  • GA ČR
Project

*In vitro diagnostics - CellKit (FR-TI2/616)

*Main goal of the project is to develop in-vitro cell based assays for testing of chemicals, cosmetic and pharmaceutical products impact on human skin. Various cell lines and materials for their imobilisation will ...

EI - Biotechnologie a bionika

  • 2010 - 2013
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  • 13 426 tis. Kč
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  • 6 883 tis. Kč
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  • MPO
Project

Monitoring DNA damage in model plants and agronomic crops exposed to environmental mutagens and agricultural chemicals (GA521/99/0532)

We propose to use a new plant based molecular genetic assay (Comet assay, single cell gel electrophoresis) to evaluate the genotoxicity of environmental the single cell gel electrophoresis assay f...

EB - Genetika a molekulární biologie

  • 1999 - 2001
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  • 2 521 tis. Kč
    • •
  • 1 654 tis. Kč
    • •
  • GA ČR
Project

Study of the endocytotic machinery via modification of viral-based nanoparticles (GA17-11397S)

will be evaluated by gene expression assays, confocal microscopy, cell fractionation, and SNAP-trap assays. Successful re-programming of viral capsids will improve. The project employs mouse polyomavirus-based na...

EA - Morfologické obory a cytologie

  • 2017 - 2021
    • •
  • 8 082 tis. Kč
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  • 7 950 tis. Kč
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  • GA ČR
Project

Influence of inositol hexaphosphate, inositol and sodium selenite on proliferation and apoptosis colorectal carcinoma cells (GP301/06/P047)

substances on cells will be determined from the point of view ofcell proliferation (metabolic activity assay - WST, bromodeoxyuridine incorporation assay - BrdU), cell in treatment of colorectal malignant cell...

FD - Onkologie a hematologie

  • 2006 - 2008
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  • 764 tis. Kč
    • •
  • 764 tis. Kč
    • •
  • GA ČR
Project

DETECTION OF AN ANTI-ISLET T-CELL REACTIVITY IN PATIENTS WITH TYPE 1 DIABETES AND IN THEIR RELATIVES (NR8127)

of insulin-producing pancreatic beta cells. The symptomless phase of the disorder could in the destruction of pancreatic beta cells . A role of T cells and MHC-restricted self antigen detection and quantification of auto-r...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 6 720 tis. Kč
    • •
  • 6 606 tis. Kč
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  • MZ
Project

Intracelular effects of uridin in the treatment of palmar-plantar erythrodyesthesia after long-term fluoropyrimidin administration- in vitro study (NS9786)

metabolites and capecitabine will be evaluated by MTT and NTCA cell viability assaysThe mechanism of uridin intracellular activity in keratinocytes (cell line HaCaT, keratinocytes primary samples) by thymidin phosphorylase...

FR - Farmakologie a lékárnická chemie

  • 2008 - 2011
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  • 2 184 tis. Kč
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  • 2 184 tis. Kč
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  • MZ
Project

Discovery of small-molecule activators of the NRF1 pathway for treatment of neurodegenerative disorders (GA22-16389S)

by employing several high-throughput cell-based assays and functional polyQ assays proteins in cells and lead to severe proteotoxic stress. The NRF1 (NFE2L1) transcription factor is a master regulator of ...

Biochemistry and molecular biology

  • 2022 - 2024
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  • 7 850 tis. Kč
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  • 7 536 tis. Kč
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  • GA ČR
Project

Identification and characterization of cancer stem cells in pediatric sarcomas. (NT13443)

(imunohistochemistry, imunofluorescence), as well as using cell lines derived from these primary tumors (cell cultures, immunofluorescence, immunoblotting, FACS, functional assaysThis project is focused on identification, ...

FG - Pediatrie

  • 2012 - 2015
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  • 8 474 tis. Kč
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  • 8 474 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 16 756