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30 (0,127s) •

Project

Mapping galectin-ganglioside networks on complex model membrane systems (GA25-15346S)

Galectins, a family of glycan-binding proteins, play pivotal roles in diverse and fundamental characteristics of galectin lattices in model biological membranes, specifically focusing on the interactions between proto-type galec...

Physical chemistry

  • 2025 - 2027
    • •
  • 9 219 tis. Kč
    • •
  • 8 841 tis. Kč
    • •
  • GA ČR
Project

Advanced high-molecular-weight glycopolymers as potent inhibitors of galectin-induced pathological processes (GA22-00262S)

Pathological overexpression of galectins is associated with several life at the design, synthesis and thorough evaluation of tailored multivalent galectin inhibitors oligosaccharides and glycomimetics with a high affinity to gal...

Polymer science

  • 2022 - 2024
    • •
  • 9 316 tis. Kč
    • •
  • 9 316 tis. Kč
    • •
  • GA ČR
Project

Studies of the mouse galectin-4 and its recombinant CRD domains in relation to the binding of sacharides and recognition of cell ligands (GA304/03/0090)

Galectins, beta-galactosides binding and soluble-type (S-type) lectins defined members. Galectin-4 represents a proto-type molecule of monomer divalent members ofgalectinsubfamily, containing also galectin-6, -8, -9, -12. R...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 2 303 tis. Kč
    • •
  • 2 303 tis. Kč
    • •
  • GA ČR
Project

Functions of galectins (-1, -3, -7) in head and neck squamous cell carcinomas (GA304/02/0463)

Galectins constitute a family of beta-galactoside binding proteins. The firstpart includes collection and immunohistochemical processing (focused on galectin-1 factors of head and neck cancer in relation to galectin-1, -3 a...

FF - ORL, oftalmologie, stomatologie

  • 2002 - 2004
    • •
  • 2 259 tis. Kč
    • •
  • 2 259 tis. Kč
    • •
  • GA ČR
Project

Mono- and multivalent inhibitors of galectin-8 in tumour-associated (lymph)angiogenesis (GF25-16301K)

Selective galectin inhibition may be applied in the theranostics of galectin-related pathologies, e.g. cancerogenesis. In this project we will prepare biocompatible mono- and multivalent carbohydrate-based ligands for selective targ...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 6 480 tis. Kč
    • •
  • 6 480 tis. Kč
    • •
  • GA ČR
Project

Neutral oligosaccharides of human milk as ligands of galectins (GA20-00215S)

diseases, in which galectins are the common denominator. Thus, galactose-rich nondigestible saccharides are an attractive natural alternative to synthetic anti-galectin mutagenesis. The affinity of prepared compounds to selected

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 5 676 tis. Kč
    • •
  • 5 676 tis. Kč
    • •
  • GA ČR
Project

Galectins as biomarkers of colorectal cancer (LTC19035)

of biosensor based on highly selective and specific interaction between human galectins galectins will be prepared by robust chemoenzymatic synthesis on a semipreparatory scale-acetylhexosaminidases) as well as human galectin

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 421 tis. Kč
    • •
  • 4 421 tis. Kč
    • •
  • MŠMT
Project

Study of galectin-glycan interactions using fluoroglycomimetics (GA23-05146S)

Non-covalent recognition of glycans by galectins mediate or modulate numerous (patho)biological processes including immune regulation, cancer, and fibrotic interactions with a panel of human galectins in both monovalent and multival...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 338 tis. Kč
    • •
  • 9 338 tis. Kč
    • •
  • GA ČR
Project

New semiconductor glyco-biosensors for selective detection of galectin biomarkers of brain cancer (LUC24024)

The main goal of the project is to develop and validate new biosensors as diagnostic tools for the future stratification of patients with brain tumors.......

Analytical chemistry

  • 2024 - 2027
    • •
  • 9 998 tis. Kč
    • •
  • 9 998 tis. Kč
    • •
  • MŠMT
Project

Library of engineered glycosidases for the preparation of bioactive glycans (LTC20072)

ligands of biomedically relevant galectins. Due to the broad substrate specificity high selectivity for particular galectins. Affinity of prepared glycostructures will be prospective for application in the therapy or prevention of ...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 3 997 tis. Kč
    • •
  • 3 997 tis. Kč
    • •
  • MŠMT
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