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5 338 (0,125s) •

Project

Study of apoptosis inhibitors as diagnostic and predictive tumor biomarkers in lung cancer (NR7860)

Analysis of expression of apoptosis inhibitors by molecular and biochemical methods in tumor tissue, lung parenchyma, biopsy and cytological samples and sputum from lung cancer patients and study of their significance as tumor

FD - Onkologie a hematologie

  • 2004 - 2008
    • •
  • 9 173 tis. Kč
    • •
  • 8 553 tis. Kč
    • •
  • MZ
Project

Combined treatment of tumor cells with chemotherapeutics and cytokines may optimize Fas-mediated apoptosis. (NC6402)

Cancer research will benefit from development of methods for optimizing the apoptotic response of tumor cells to Fas-mediated signals.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 834 tis. Kč
    • •
  • 1 834 tis. Kč
    • •
  • MZ
Project

Mechanisms of resistance to induction of apoptosis in tumor cells (GA301/01/0041)

Resistance to apoptosis induction is an important feature of cancer cells which is associated with increased resistance to the therapy. The aim of the proposed research is to describe the mechanism responsible for the resistance to ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 3 594 tis. Kč
    • •
  • 2 053 tis. Kč
    • •
  • GA ČR
Project

Death of a tumor cell by apoptosis - mechanisms of regulation, methods of detection and therapeutic implications (GV301/96/K047)

Studies of genetically determined programmed cell death by apoptosis and gradual recognition of the signalling and regulatory pathways which control apoptosis the proportionality of apoptoic cells in the tumor<...

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 8 538 tis. Kč
    • •
  • 8 296 tis. Kč
    • •
  • GA ČR
Project

Delineation of molecular mechanisms enhancing death-receptor mediated apoptosis in tumor cells (GA301/03/0545)

Defects in the molecular mechanisms controling either cell division or apoptosis can lead to malignancies. The biochemical machinery of cell death comprises caspases that can be activated by the engagement of surface death ...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 792 tis. Kč
    • •
  • 792 tis. Kč
    • •
  • GA ČR
Project

HMGB1 role in modulation of tumor suppressors and telomere integrity (GA204/05/2031)

p53 is a crucial tumor suppressor for preventing malignant transformation of cells by inducing cell-cycle arrest and apoptosis. These two mutually exclusive including DNA replication, recombination, transcription, ...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 528 tis. Kč
    • •
  • 3 528 tis. Kč
    • •
  • GA ČR
Project

Topographic and functional characterization of telomeres in various tumor cell lines determined in situ and in vivo (GP204/05/P090)

of telomeres during cell cycle, apoptosis, and after cell fusion in healthy cells and tumorAll human tumors as well as immortalized cell lines, which have been analyzed and thus stabiliz...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 175 tis. Kč
    • •
  • 1 175 tis. Kč
    • •
  • GA ČR
Project

Mechanism of apoptosis induction by iron deprivation in tumor cells. (GA301/97/1029)

deprivation can induce apoptosis in tumor cells are of particular interest. The aim of proposed research is to describe the mechanism of apoptosis induction by iron induction of apoptosis (programmed ...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 2 080 tis. Kč
    • •
  • 1 346 tis. Kč
    • •
  • GA ČR
Project

Removing tumour cells defences Defining and inhibiting the survival pathways exploited by tumour cells that suppress Fas-mediated apoptosis (GA301/00/0563)

induces apoptosis in sensitive cells. Fas-mediated apoptosis is often suppressed in tumors that originate from Fas-sensitive tissues. However, it is poorly understood. Molecular survival pathways which might inhib...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 802 tis. Kč
    • •
  • 1 552 tis. Kč
    • •
  • GA ČR
Project

Introduction of DNA microarray methodology and its application in antitumor therapy (1K04017)

helps to define differences between normal and tumor cells and reveal possible anticancer therapy. Key differentially expressed genes in tumor cells will be definedMalignant cell transformation is charact...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 7 428 tis. Kč
    • •
  • 3 177 tis. Kč
    • •
  • MŠMT
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