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2 545 (0,088s) •

Project

The role of antimicrobial peptides in plant defense against pahogenic microorganisms (GA522/09/1693)

of them is synthesis of small cationic peptides with antimicrobial activities. Our, modification and synthesis or production of the short peptide structures based on plant peptides, differing in primary structure and fulfi...

EE - Mikrobiologie, virologie

  • 2009 - 2013
    • •
  • 6 823 tis. Kč
    • •
  • 6 823 tis. Kč
    • •
  • GA ČR
Project

Potential of EGF-like peptides and synthetic analogues of cAMP to enhance developmental capacity of pig oocytes cultured in vitro (GA523/08/0111)

The aims of this project are to characterize signaling pathways activated oocytes is induced by LH-stimulated production of EGF-like peptides in mural granulosa cells. We will assess expression of the EGF-like peptides in p...

ED - Fyziologie

  • 2008 - 2010
    • •
  • 2 444 tis. Kč
    • •
  • 2 444 tis. Kč
    • •
  • GA ČR
Project

Peptides controlling membrane curvature (LUC25012)

The project focuses on lipid membrane curvature and peptides that are sensitive transport, and cell signaling. Modulation of membrane curvature is also associated. The main aim of this project is the creation of a peptide l...

Biophysics

  • 2025 - 2027
    • •
  • 4 689 tis. Kč
    • •
  • 4 689 tis. Kč
    • •
  • MŠMT
Project

Signaling pathways and genes regulating gonadotropin-induced maturation of pig cumulus-oocyte complexes (GAP502/11/0593)

The aim of the proposed project is to define signaling pathways and genes in vitro. The gonadotropins induce synthesis of EGF-like peptides in cumulus cells will find out what signaling pathways and genes are activated by t...

ED - Fyziologie

  • 2011 - 2014
    • •
  • 9 315 tis. Kč
    • •
  • 9 315 tis. Kč
    • •
  • GA ČR
Project

Lipidized analogs of prolactin-releasing peptide as potential agents for obesity therapy search for mechanism of action (GA18-10591S)

Anorexigenic neuropeptides such as prolactin-releasing peptide (PrRP) are potential anti-obesitics but they are unable to exert their exclusively central effect anorexigenic peptides. In this project, we aim to design and synthesize...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2020
    • •
  • 10 641 tis. Kč
    • •
  • 9 249 tis. Kč
    • •
  • GA ČR
Project

Membrane proteases in cell differentiation. Mechanisms of their function and their particip. in the activation of biol. active synthetic peptide precursors (GA303/96/1482)

Membrane proteases are involved in mechanism of signal transduction, cell adhesion and degradation of biologically active peptides. Enzyme activity and expression changes during cell differentiation have been observed in various cel...

CE - Biochemie

  • 1996 - 1998
    • •
  • 1 710 tis. Kč
    • •
  • 1 438 tis. Kč
    • •
  • GA ČR
Project

Neuropeptide FF-2 receptor as a potential anti-obesity target Impact of new analogs of RF-amide peptides (GA21-03691S)

and energy expenditure. This project deals with two RF-amide peptides, prolactin-releasing peptide (PrRP) and neuropeptide FF (NPFF), and their receptors GPR10 and NPFF administration. In this project we would like to design and se...

Physiology (including cytology)

  • 2021 - 2023
    • •
  • 11 297 tis. Kč
    • •
  • 10 676 tis. Kč
    • •
  • GA ČR
Project

Signal transduction of angiotensin II in diabetes mellitus and its modulation by glucose, insulin a insulin resistance (NR8221)

vascular complications. Signaling of this peptide has not been sufficiently studied signalingin diabetes and their synergism with insulin and glucose signaling. Using animal receptor, factors important for smooth Ang II

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 049 tis. Kč
    • •
  • 4 585 tis. Kč
    • •
  • MZ
Project

Effect of different types of antidiabetic interventions on the development of neurodegenerative changes in brain of diabetic mice (GAP303/12/0576)

to disturbed central insulin signaling in type 2 diabetes mellitus (T2DM). Insulin, leptin and glucagon-like peptide-1 (GLP-1) agonists were shown to prevent pathological phosphorylation of Tau protein and/or formation of Amyloid b...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2014
    • •
  • 8 919 tis. Kč
    • •
  • 8 919 tis. Kč
    • •
  • GA ČR
Project

Visual and/or fluorescent molecular recognition of cyclic nucleotides with azo-bridged cyclic peptide libraries (GA203/04/1421)

will synthesizeAzo-Peptide-Macro-Cycles libraries of tetra-, penta- and hexapeptides of signaling systems in visual or fluorescence mode. In the synthesis, a water compatible-compound libra­ries will be used. Therefore, each pe...

CC - Organická chemie

  • 2004 - 2006
    • •
  • 2 662 tis. Kč
    • •
  • 2 662 tis. Kč
    • •
  • GA ČR
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