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1 435 (0,085s)

Project

Lipids of bumblebees and their role in the biosynthesis of pheromonal components (IAA4055403)

Storage, mobilisation, transport, and metabolism of lipids in different components of the male marking pheromone. Composition of lipids in different species will be determined. Storage form of lipids in th...

CC - Organická chemie

  • 2004 - 2008
  • 2 650 tis. Kč
  • 2 650 tis. Kč
  • AV ČR
Project

Genetic and correlation analyses of lipidome in rat model of metabolic syndrome for identification of disease biomarkers (GA16-04859S)

Aberrant lipid metabolism, such as hyperlipidemia, play important role in the pathogenesis of metabolic syndrome. Lipids have distinct functions such as cellular structure, trafficking, signaling, and energy storage. In the...

EB - Genetika a molekulární biologie

  • 2016 - 2018
  • 6 171 tis. Kč
  • 5 976 tis. Kč
  • GA ČR
Project

Dietary and pharmacological modulation of SCD1 as a tool for studying the link between ectopic lipid storage and insulin sensitivity in obesity (GA17-11027S)

Obesity is associated with insulin resistance and excessive lipids in non-adipose tissues, i.e. ectopic lipids. We have shown in mice that dietary intervention SCD1 inhibition on ectopic lipids and insulin sensitivity (meas...

ED - Fyziologie

  • 2017 - 2021
  • 7 246 tis. Kč
  • 7 000 tis. Kč
  • GA ČR
Project

Multidimensional chromatography - mass spectrometry quantitative workflows in detailed characterization of human plasma lipidome (GA21-20238S)

Lipids are important biomolecules with various functions in cell membranes, signaling, and energy storage, which exhibit a huge structural diversity in the nature. The dysregulation of lipids can directly reflect various pa...

Analytical chemistry

  • 2021 - 2023
  • 9 310 tis. Kč
  • 9 310 tis. Kč
  • GA ČR
Project

Mechanisms and consequences of tissue triglyceride and fatty acid derivatives accumulation in insulin resistance - a possible impact of hypolipidemic therapy. (NR8495)

, their utilization, storage, and DAG and LCFA-CoA will be determined. Gene expression profiling in liver, adipose tissue and muscle provide information about localization of lipid and the implications for the storage and m...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
  • 4 452 tis. Kč
  • 4 223 tis. Kč
  • MZ
Project

Novel Insights into the Nanostructure of the Skin Lipid Barrier by Biophysical Methods (GF22-20839K)

The skin lipid barrier, an extracellular ceramide-based multilamellar lipid mechanisms and conditions of lipid assembly into a functional barrier and the exact of these lipids´ nanoscopic architecture, probe the ro...

Biophysics

  • 2022 - 2025
  • 7 911 tis. Kč
  • 7 911 tis. Kč
  • GA ČR
Project

The role of lipids and lipid-metabolizing enzymes in plant autophagy (LTC17084)

The main objective of the project is elucidation of involvement of lipids and lipid-metabolizing enzymes in plant autophagy. In order to achieve the main of lipid metabolism knockout mutants with altered autophagy, verifica...

ED - Fyziologie

  • 2017 - 2020
  • 3 688 tis. Kč
  • 3 688 tis. Kč
  • MŠMT
Project

*New procedures of the lipid micro- and nanodispersion systems formulation as the transport systems of pharmacological active substances (2A-1TP1/015)

*The aim of the project is to indroduce new technological procedures of lipid emulsions and solid lipid nanodispersion formulation and to utilize them as carriers of drugs mainly for per oral and topical administrations.......

JP - Průmyslové procesy a zpracování

  • 2006 - 2011
  • 15 011 tis. Kč
  • 9 201 tis. Kč
  • MPO
Project

How lipid asymmetry influences membrane protein function (GF25-19982L)

, characterized by distinct lipid compositions in their two leaflets, most studies use, elucidating the structural and dynamical properties of lipids in asymmetric membranes and their interactions with integral membrane proteins, fo...

Biophysics

  • 2025 - 2027
  • 5 318 tis. Kč
  • 5 318 tis. Kč
  • GA ČR
Project

Understanding the mechanisms of epidermal lipid barrier formation, damage and repair implications for skin diseases (GA25-17203S)

mechanisms of the formation of this hydrophobic, ceramide-rich lipid mixture teams, combining methods of lipid synthesis, analysis and biophysics of formation of human barrier lipid assemblies and the conditions for their ...

Pharmacology and pharmacy

  • 2025 - 2027
  • 11 956 tis. Kč
  • 11 704 tis. Kč
  • GA ČR
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