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3 018 (0,07s) •

Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

of phenotypically relevant mutants of retroviral matrix protein (MA), which is common to all replication competent viruses. MA protein forms the outer protein shell of a mature virion andplays a key role in the process of ...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
Project

Structural study of protein p12 from Mason-Pfizer monkey virus using NMR spectroscopy (GP203/02/P098)

is cleaved by protease yielding six proteins: p10 (matrix protein - MA), pp24/18, p12, p27 (capsid protein - CA), p14 (nucleocapsid protein - NC) and p4. The functions, that this protein supports...

CE - Biochemie

  • 2002 - 2004
    • •
  • 359 tis. Kč
    • •
  • 209 tis. Kč
    • •
  • GA ČR
Project

Study of inhibition of multimerization of retroviral capsid protein from HIV-1 (IAB4055202)

The aim is to develop an assay for testing inhibitors of dimerization of capsid proteins (CA). CA, as a part of Gag polyproteins plays a crucial role in assembly of innature capsids mediating the Gag-Gag interactions. CA di...

CE - Biochemie

  • 2002 - 2004
    • •
  • 1 879 tis. Kč
    • •
  • 1 403 tis. Kč
    • •
  • AV ČR
Project

Structural study of protein domains of monkey retrovirus (IAA4055304)

Temporal and spatial separation of assembly of immature capsid particles from their release makes Mason-Pfizer monkey virus (M-PMV), inducing an AIDS like syndrom in non of the scaffolding protein p12 and the 13 kDa form of M-PMV pr...

CE - Biochemie

  • 2003 - 2007
    • •
  • 11 354 tis. Kč
    • •
  • 4 282 tis. Kč
    • •
  • AV ČR
Project

The construction of retroviral particles with their potential use as a therapeutic delivery systems (KJB501270701)

(M-PMV), namely mutated fusion capsid and nucleocapsid protein ((pro-)CANC and the presence of nucleic acids. The goal of this project is optimization of M-PMV capsid. We will prepare modified protein which will c...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 1 209 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • AV ČR
Project

Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)

model system for its intracytoplasmic assembly of capsid shell. A point mutation in M-PMV matrix protein (MA) can alter the morphogenesis of D-type to that of C-type (e.g. HIV-1) which assembles its capsids at the plasma m...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 843 tis. Kč
    • •
  • 1 809 tis. Kč
    • •
  • GA ČR
Project

In vitro preparation of recombinant capsids for nucleic acids incorporation and internalization in the cell tissue (GP203/03/P094)

on determination of minimal required proteins and theirdomains responsiblefor this process. We will further study binding of nucleic acids to proteins forming viral capsids. Our goal is to improve binding capacities and to...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

Design, characterization and mechanism of action of novel inhibitors of HIV assembly (GA13-19561S)

of HIV capsid protein, thereby preventing virus assembly. The design will be based the interaction of the C-terminal domain of HIV capsid protein with a peptide inhibitor......

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 11 267 tis. Kč
    • •
  • 11 267 tis. Kč
    • •
  • GA ČR
Project

Interactions of flaviviral genomic and subgenomic RNA with host and viral proteins (GA18-27204S)

) the interactions of the viral genomic RNA with the capsid protein responsible for nucleocapsid assembly, including determination of the TBEV C protein structure; (ii) functional......

Virology

  • 2018 - 2021
    • •
  • 12 536 tis. Kč
    • •
  • 11 669 tis. Kč
    • •
  • GA ČR
Project

Structure of retroviral particle and intracellular transport of its components. (LH12011)

Vectors expressing fluorescently tagged envelope and structural protein mutants of M-PMV altering assembly, transport or capsid release will be prepared. ?Live imaging? established in US laboratory will be employed for analysis of <...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 1 990 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • MŠMT
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