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288 (0,075s) •

Project

Regulation of Th1/Th2 cytokine profile in organ transplantation (NI6843)

The aim of the proposed study os to characterize the relationship between the induction of alloreactive T lymphocytes and their capacity to produce Th1 or Th2 cytokines in mixed lymphocyte cultures (MLC) and in patients after kidney transplantation. ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2001 - 2003
    • •
  • 3 813 tis. Kč
    • •
  • 3 461 tis. Kč
    • •
  • MZ
Project

The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity to interferon therapy. (NC7139)

and interactions affect the response of malignant melanoma to IFN-alpha/gamma treatment induced by IFNs in melanoma and normal cells will be examined using immunoblotting to interferon treatment in individual patients and ...

EC - Imunologie

  • 2002 - 2004
    • •
  • 6 107 tis. Kč
    • •
  • 6 059 tis. Kč
    • •
  • MZ
Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

administration of IFN gamma, which is hypotratically capable to revert the MHC I- to MHC I...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

The role of IFN-gamma in the immune response against microsporidial infection (GP524/03/D167)

of theproject is to analyse the role of interferon gamma in peroral or intraperitoneal immunodeficient (SCID) mice, specific depletion of lymphocyte subsets, or interferon gamma......

EC - Imunologie

  • 2003 - 2006
    • •
  • 1 087 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Activation of HIV-Specific CD8+ T Lymphocytes by IL-2 and Histamine Possible Use in Therapy? (NR9032)

will investigate the production of IFN-gamma by ELISPOT and production of Perforine. Weexpect and IFN-gammaHistamine induces activation of cytotoxic CD8+ T Lymphocytes and improves......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2006 - 2008
    • •
  • 2 200 tis. Kč
    • •
  • 2 200 tis. Kč
    • •
  • MZ
Project

Intracellular complement alterations in patients with allergic eosinophilic asthma. (NU20-05-00146)

Allergic eosinophilic asthma (AEA) is one of the most common types of asthma, representing 75% of all cases. Th2 lymphocyte-mediated inflammation is assumed to be the pathological mechanism of AEA. AEA patients have elevated serum gelatinase B (MMP9)...

Immunology

  • 2020 - 2025
    • •
  • 12 372 tis. Kč
    • •
  • 12 290 tis. Kč
    • •
  • MZ
Project

Gene therapy of cancer utilisation of the synergistic effects of antitumor cytokines (GA301/00/P021)

, IFN alpha, IFN gamma and GM-CSF. The optimal combination of cytokines...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 216 tis. Kč
    • •
  • 216 tis. Kč
    • •
  • GA ČR
Project

New tools for rapid and non-invasive diagnosing of latent infections. (2B06161)

will be designed and characterized for the capacity to promote IFN-gamma release by re...

EE - Mikrobiologie, virologie

  • 2006 - 2011
    • •
  • 30 644 tis. Kč
    • •
  • 27 424 tis. Kč
    • •
  • MŠMT
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to HIV-1-infected lymphocytes induces robu...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

(IFN) alpha in human organism, in pathogenesis of hepatitis B virus (HBV) infection is not clear. We hypothesize that pDCs could be involved via production of IFN-alpha hepatitis B (CHB) treatment, and a major target of IFN

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 288