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3 231 (0,112s) •

Project

Clinical significance of minimal residual disease in patients with operable lung cancer (NS10285)

and systemic therapy using specific markers (CEA, c-met messenger RNA, EGFRand VEGFR mRNA...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 4 989 tis. Kč
    • •
  • 4 823 tis. Kč
    • •
  • MZ
Project

Non-coding RNAs matters role in mammalian oocyte and embryo (GA18-19395S)

development. In addition to protein-coding messenger RNAs, oocytes and embryos produce a plethora of diverse non-coding RNA molecules. Subpopulation of non-coding RNAs belongs to the short and long non-coding ...

Reproductive biology (medical aspects to be 3)

  • 2018 - 2021
    • •
  • 6 033 tis. Kč
    • •
  • 5 640 tis. Kč
    • •
  • GA ČR
Project

Control of plant viruses by RNA based vaccines (LD12071)

that have been obtained by the traditional breeding and/or genetic engineering till now. The novel non-transgenic strategy based on using of artificial RNA-inducer molecules (so called RNA-vaccines) to induce virus degrada...

EB - Genetika a molekulární biologie

  • 2012 - 2013
    • •
  • 542 tis. Kč
    • •
  • 542 tis. Kč
    • •
  • MŠMT
Project

RNA for therapy (EH22_008/0004575)

and immunotherapy, as well as to address genetic, infectious, and chronic diseases linked to RNA metabolism. The project combines cutting-edge research on key molecular mechanisms in RNAThe project aims to develop a Czech-...

Biochemistry and molecular biology

  • 2024 - 2028
    • •
  • 499 641 tis. Kč
    • •
  • 126 409 tis. Kč
    • •
  • MŠMT
Project

A Reverse Genetic Approach to Study Steroid Response in Lepidopteran Insects (IAB5007002)

pathway in lepidopteran insects using the innovative reverse genetic approach of RNA-drosophilid insects are unknown due to the lack of genetic evidence. To define some discriminante between nuclear receptor isoforms. Role...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 2 056 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • AV ČR
Project

Implication of placenta-specific microRNAs in maternal circulation for diagnosis and prediction of placental insufficiency (GAP304/12/1352)

MicroRNAs (miRNAs) belong to a family of small non-coding RNAs (18-25 nucleotides) that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. Recent ...

FK - Gynekologie a porodnictví

  • 2012 - 2014
    • •
  • 5 259 tis. Kč
    • •
  • 5 259 tis. Kč
    • •
  • GA ČR
Project

Complex clinical, immunological and genetic analysis of autoinflammatory diseases (NU21-05-00522)

). As genetic analysis may not be readily available, feasible and reliable diagnostic prompt appropriate management. Nevertheless, even genetic analysis does not always. Genetic confirmation not only labels the diagnosis, b...

Immunology

  • 2021 - 2025
    • •
  • 12 478 tis. Kč
    • •
  • 12 411 tis. Kč
    • •
  • MZ
Project

The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing. (IAA500960705)

The RNA metabolism of trypanosomatids has many unusual aspects, e.g U-insertion/deletion RNA editing. Much research has focused on the core RNA editing machinery structure, that the MRP protein complex has a multifarious ro...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 911 tis. Kč
    • •
  • 4 911 tis. Kč
    • •
  • AV ČR
Project

Characterization of dynamical regions in RNA polymerase from Bacillus subtilis (GJ18-04197Y)

RNA polymerase is responsible for one of the key cellular mechanisms. It transcribes the genetic information stored in DNA into RNA. This project focuses on a characterization of dynamical parts of the RNA polymera...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 4 670 tis. Kč
    • •
  • 4 670 tis. Kč
    • •
  • GA ČR
Project

Catalytic strategies of RNA and RNP enzymes studied by multi-scale computational approach (GAP208/12/1878)

The non-coding RNAs play decisive roles in expression and regulation of genetic information. Among them catalytic RNAs (ribozymes) have high biological, the understanding of physical-chemistry of RNA catalysis lags...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2016
    • •
  • 7 930 tis. Kč
    • •
  • 7 930 tis. Kč
    • •
  • GA ČR
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