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922 (0,083s)

Project

Intestinal permeability in patients with inflammatory bowel disease - the role in pathogenesis and monitoring of the course of the disease and its treatment. (NB4529)

Measurment of intestinal permeability using lactulose(mannitol test in patients with inflammatory bowel disease. The barrier function of the small intestine in pathogenesis of inflammatory bowel disease,monitoring of the cl...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
  • 1 357 tis. Kč
  • 1 210 tis. Kč
  • MZ
Project

A new generation of in vitro intestinal barrier models for evaluating the effects of drugs and food ingredients (LUC25122)

be summarized as follows: - Creation of an advanced model of the physiological intestinal barrier - Colonization of the physiological intestinal barrier with microbiota - Preparation of a pathological model of the...

Biochemistry and molecular biology

  • 2025 - 2028
  • 4 996 tis. Kč
  • 4 996 tis. Kč
  • MŠMT
Project

Study on association between intestinal microbiome and increased risk of chronic inflammatory diseases of locomotor system, osteoporosis and rheumatoid arthritis. (NV18-05-00394)

in postmenopausal women may adjust the intestinal barrier and thus affect the speed and degree of the intestinal barrier disorders, their association with chronic inflammation, their use of gut barrier co...

General and internal medicine

  • 2018 - 2022
  • 13 802 tis. Kč
  • 13 776 tis. Kč
  • MZ
Project

Modulating the inflammatory response in the gut by targeting the aryl hydrocarbon receptor as a therapeutic goal (NW25-05-00121)

The intestinal epithelium establishes a selectively permeable barrier between) plays a key role in maintaining intestinal epithelial barrier function and mucosal of intercellular junction proteins. As a result, dam...

Biochemistry and molecular biology

  • 2025 - 2028
  • 13 886 tis. Kč
  • 13 886 tis. Kč
  • MZ
Project

Development of new tools for diagnosis and therapy of CrohnŮs disease and ulcerative colitis (1QS500200572)

for detection of intestinal barrier impairment, detection of changes in intestinalCrohnŮs disease and colitis ulcerosa are severe chronic disorders afflicting children and young adults. Based on our previous studies concer...

FE - Ostatní obory vnitřního lékařství

  • 2005 - 2009
  • 11 875 tis. Kč
  • 11 675 tis. Kč
  • AV ČR
Project

The development of diagnostic panel for monitoring of perioperative small bowel injury (NT13536)

of intestinal damage it is necessary to develop a chemistry panel of validated markers...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
  • 4 989 tis. Kč
  • 4 989 tis. Kč
  • MZ
Project

The effect of anti IL-17 therapy on skin and gut microbiota and intestinal barrier function in psoriasis patients (NU22J-05-00056)

virulent commensal strains that can compromise the already fragile gut barrier barrier integrity over psoriatic patients on local therapy. This is because the integrity of the skin barrier as well. New biomarkers associate...

Immunology

  • 2022 - 2025
  • 6 524 tis. Kč
  • 6 524 tis. Kč
  • MZ
Project

The role of bacteria and the diet in the development of celiac disease (GPP304/10/P406)

the intestinal barrier function and protect against CD development. The interplay betweenCeliac disease (CD), an immunologically mediated intestinal disorder, is induced by dietary gluten and prolamins in genetically predi...

EC - Imunologie

  • 2010 - 2010
  • 599 tis. Kč
  • 599 tis. Kč
  • GA ČR
Project

In vitro and ex vivo models to study drug-drug interactions of antiviral drugs on intestinal transporters (GJ18-07281Y)

circulation by absorption in the intestine. Level of the absorption is often significantly since year 2012. Some of them have already been reported to interact with intestinal has high interaction potential at the level of inte...

Pharmacology and pharmacy

  • 2018 - 2022
  • 4 967 tis. Kč
  • 4 967 tis. Kč
  • GA ČR
Project

The composition of the oral and intestinal microbiome as a predictor for response to therapy in patients with head and neck carcinoma (NU23-03-00274)

sensitivity. Furthermore, RT/CRT distorts the intestinal barrier. This process can lead effects. It was established that oral and intestinal bacteria can contribute composition of oral/intestinal microbiota, pre-e...

Otorhinolaryngology

  • 2023 - 2026
  • 12 359 tis. Kč
  • 12 359 tis. Kč
  • MZ
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