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11 003 (0,095s) •

Project

Neuroprotective effects of novel analogs of anorexigenic prolactin-releasing peptide (PrRP) in mouse models of neurodegeneration and obesity (GA16-00918S)

plaques in animal models of AD. The major aim of our proposal is to find out if novel anorexigenic peripherally administered and centrally acting analogs of prolactin-releasing. Implication of PrRP analogs on spatial memor...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2018
    • •
  • 8 583 tis. Kč
    • •
  • 7 815 tis. Kč
    • •
  • GA ČR
Project

Neuropeptide FF-2 receptor as a potential anti-obesity target Impact of new analogs of RF-amide peptides (GA21-03691S)

will be also determined. The proposed KO models will help to prepare specific analogs-2R, respectively. We have already demonstrated that lipidized PrRP analogs analogs with best affinity to and activation of sign...

Physiology (including cytology)

  • 2021 - 2023
    • •
  • 11 297 tis. Kč
    • •
  • 10 676 tis. Kč
    • •
  • GA ČR
Project

Sophisticated methods of the analog and mixed-signal circuits design in sub-micron technologies (GA102/07/1186)

of synthesis and multi-criteria design optimization of analog sontinuous- and discrete-time to the to the synthesis and optimized design of discrete- and continuous-time analog and mixed signal integrable building blocks and sub-pa...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2007 - 2009
    • •
  • 1 677 tis. Kč
    • •
  • 1 677 tis. Kč
    • •
  • GA ČR
Project

Lipidized analogs of prolactin-releasing peptide as potential agents for obesity therapy search for mechanism of action (GA18-10591S)

that lipidized PrRP analogs bound to PrRP receptor GPR10, decreased body weight and ameliorated metabolic parameters in rodent models of obesity after peripheral of lipidized PrRP analogs and compare their affinity to and ...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2020
    • •
  • 10 641 tis. Kč
    • •
  • 9 249 tis. Kč
    • •
  • GA ČR
Project

Structure and dynamics of shallow salt sheet extrusion investigated by means of magnetotellurics, gravity and analog & numerical modelling (GA24-11150S)

. Further, extrusion and growth will be simulated in analog experiments and numerical...

Geology

  • 2024 - 2026
    • •
  • 9 352 tis. Kč
    • •
  • 9 352 tis. Kč
    • •
  • GA ČR
Project

Computer modeling and synthesis of digital and mixed analog-digital systems (GA102/05/0732)

and mixed analog-digital systems using up-to-date, in particular behavioral description into PLD, FPGA and ASIC devices. As one application of the developed methods, model of the model, a sample optical link will be built ...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2005 - 2007
    • •
  • 1 641 tis. Kč
    • •
  • 1 641 tis. Kč
    • •
  • GA ČR
Project

The possible role of stable analogs of prolactin-releasing peptide in experimental models of obesity and hypertension (GA15-08679S)

PrRP analogs modified with fatty acid that would prolong their half-life and enable them to cross blood brain barrier. PrRP analogs will be subjected to binding and chronic effect of PrRP analogs on blood pressure and its ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2017
    • •
  • 9 867 tis. Kč
    • •
  • 9 867 tis. Kč
    • •
  • GA ČR
Project

Advanced methods of computer-aided circuit design (GA102/05/0771)

mathematical model that allows analytical solution. The proposed approach is based simple in order to se up a solvable analytical model of the system designed application in all the institutions that deal with computer-aided design...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2005 - 2007
    • •
  • 1 297 tis. Kč
    • •
  • 1 297 tis. Kč
    • •
  • GA ČR
Project

Synthesis of cyclic oligosaccharides containing 2-amino-2-deoxy-hexopyranoses and study of their complexation activity (GA203/00/0071)

Cyclodextrins and their analogs belong to the group of macrocyclic compounds orthogonally protected monosaccharide units. The modified cyclodextrin analogs of this type cyclodextrin analogs obtained in this way allow for su...

CC - Organická chemie

  • 2000 - 2002
    • •
  • 1 759 tis. Kč
    • •
  • 1 174 tis. Kč
    • •
  • GA ČR
Project

Current- and hybrid-mode circuits for analog signal processing (GA102/05/0277)

The project substance consists in the improvement of the current and the development of new methods of analog filtering on the basis of active current- and mixed-mode elements. From the active elements which offer some of their input or outp...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2005 - 2007
    • •
  • 3 747 tis. Kč
    • •
  • 3 747 tis. Kč
    • •
  • GA ČR
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