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834 (0,087s) •

Project

The appreciacion of clinical development of opportunistic infection in the relation to immunological profile in HIV+ patients. (IZ2330)

9F - 9

  • 1994 - 1996
    • •
  • 959 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • MZ
Project

Organisation and function of CD4 co-receptor on the surface of T cells at nanoscale (GA15-06989S)

CD4 glycoprotein functions as a co-receptor for the activation of T cells by their main receptor, TCR. The ultimate function of CD4 is the delivery of the proximal of T cells. Different pools of CD4 molecu...

EC - Imunologie

  • 2015 - 2019
    • •
  • 7 753 tis. Kč
    • •
  • 7 753 tis. Kč
    • •
  • GA ČR
Project

Distinct roles of IL-2 for antigen-primed CD8+ and CD4+ T cells a paradigm shift in T cell biology and implication for cancer immunotherapy (GA25-16348S)

+ and CD4+ T cells. This project aims to change the current paradigm in the field, but it is a dispensable cytokine for activated CD4+ T cells and it can even dampen their expansion, in particular, exhibits signifi...

Immunology

  • 2025 - 2027
    • •
  • 8 997 tis. Kč
    • •
  • 8 997 tis. Kč
    • •
  • GA ČR
Project

Topological regulation of CD4 and CD8 in T cells (GA19-07043S)

Co-receptors CD4 and CD8 are essential for the development and function of T cells. However, molecular mechanism how CD4, and to some extend CD8, modulate T cell possible precision of ~20 nm in 3D. We will further ...

Immunology

  • 2019 - 2022
    • •
  • 8 341 tis. Kč
    • •
  • 7 947 tis. Kč
    • •
  • GA ČR
Project

Role of virus-associated host-derived proteins in virus induced T cell dysfunction (GAP304/10/1161)

, are enveloped viruses, which infect CD4 T cells and cause transient (VZV) or progressive (SIV) dysregulation of T cell function. This effect is mainly indirect of these host cell proteins will be subsequently investigated...

EC - Imunologie

  • 2010 - 2016
    • •
  • 4 685 tis. Kč
    • •
  • 4 685 tis. Kč
    • •
  • GA ČR
Project

Cellular Immunology in Renal Transplantation Frequencies of Cytotoxic T Lymphocyte Precursors as a Prognostic Marker. (IZ2027)

9F - 9

  • 1994 - 1996
    • •
  • 434 tis. Kč
    • •
  • 661 tis. Kč
    • •
  • MZ
Project

Cellular immunology in kidney transplantation - nonrestricted versus self-restricted cytotoxic T lymphocytes (IZ4198)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1998
    • •
  • 600 tis. Kč
    • •
  • 600 tis. Kč
    • •
  • MZ
Project

Experimental model of colitis. Dysregulation of the immune response to the gut microflora (GA303/00/1370)

The aim of the project is to determine a role CD4+ CD45RBhigh T lymphocytes of experimental colitis occuring in CD4+ CD45RBhigh - reconstituted conventional SCID mice. Effector CD4+ CD45RBhigh T lymphocyte...

EC - Imunologie

  • 2000 - 2002
    • •
  • 2 558 tis. Kč
    • •
  • 2 160 tis. Kč
    • •
  • GA ČR
Project

Immunomodulation in the treatment of children with frequent respiratory infections. (IZ2169)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1994 - 1997
    • •
  • 700 tis. Kč
    • •
  • 941 tis. Kč
    • •
  • MZ
Project

Intracellular complement alterations in patients with allergic eosinophilic asthma. (NU20-05-00146)

activation of CD4+ T cells. This process is influenced also by intracellular complement system. Activation of CD4+ T cells can be pharmacologically influenced by vitamin D is focused on changes of iTreg, CD46, C3a...

Immunology

  • 2020 - 2025
    • •
  • 12 372 tis. Kč
    • •
  • 12 290 tis. Kč
    • •
  • MZ
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