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1 219 (0,162s) •

Project

Nanomechanics of RNA and DNA structural motifs (GA14-21893S)

RNA and DNA motifs are recurrent structural building blocks found dynamics (MD) simulation data of selected RNA and DNA molecules. We will adopt formulated mechanical models of the motifs. RNA non-helical motifs such as int...

BO - Biofyzika

  • 2014 - 2016
    • •
  • 2 668 tis. Kč
    • •
  • 2 668 tis. Kč
    • •
  • GA ČR
Project

Structural dynamics, molecular interactions and function of key RNA motifs (GA203/09/1476)

of stochastic flexibilities of basic RNA building blocks. Both features are crucial for function of RNAs but are very difficult to assess by experiments. The research will mainly be directed to key medium-sized autonomous ...

CF - Fyzikální chemie a teoretická chemie

  • 2009 - 2012
    • •
  • 2 812 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • GA ČR
Project

Characterization of dynamical regions in RNA polymerase from Bacillus subtilis (GJ18-04197Y)

RNA polymerase is responsible for one of the key cellular mechanisms. It transcribes the genetic information stored in DNA into RNA. This project focuses on a characterization of dynamical parts of the RNA polymerase that a...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 4 670 tis. Kč
    • •
  • 4 670 tis. Kč
    • •
  • GA ČR
Project

Mechanical properties of RNA and DNA structural building blocks (GA17-14683S)

Natural and artificial RNA and DNA structures are composed of recurrent of cytosine methylation on DNA mechanics, and DNA with structural lesions. In the RNA laboratories. The results will elucidate mechanical properties of DNA and ...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 4 017 tis. Kč
    • •
  • 3 756 tis. Kč
    • •
  • GA ČR
Project

DNA SPECIFICITY-DETERMINING SUBUNITS OF BACTERIAL RNA POLYMERASE WITH FLEXIBLE DOMAINS FUNCTION AND DYNAMICS (GA13-16842S)

In G+ bacteria, the delta and sigma subunits of RNA polymerase (RNAP) are critical determinants of its specificity for DNA promoter sequence. Both the delta and vegetative sigmaA (SigA) subunits contain domains that move relative to the rest...

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 11 495 tis. Kč
    • •
  • 11 495 tis. Kč
    • •
  • GA ČR
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

RNA-based therapy is revolutionizing the healthcare strategy worldwide. The flexible design of RNA molecules combined with the scalability and tunability of lipid nanoparticles, make RNA-nanotherapeutics a promisin...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • MZ
Project

The importance of having YS phosphorylated. Investigation of interaction between CTD and transcription elongation factor Spt6 (GA15-24117S)

Histone chaperon Spt6 is highly conserved and essential protein that functions in transcription elongation, chromatin maintenance, and RNA processing. Spt6 is required for recruitment of RNA processing factors to elongating RNA<...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 9 153 tis. Kč
    • •
  • 9 153 tis. Kč
    • •
  • GA ČR
Project

Towards the understanding of the CTD code of RNA Polymerase II (GA13-18344S)

I propose to decipher the basic rules that govern the readout of the CTD code of RNA polymerase II (RNAPII) by processing factors. The concept of the CTD code were unsuccessful due to flexibility of the CTD and its weak binding affi...

CE - Biochemie

  • 2013 - 2017
    • •
  • 12 739 tis. Kč
    • •
  • 12 739 tis. Kč
    • •
  • GA ČR
Project

Mapping the conformational space of the riboswitches (GA18-25349S)

cannot be directly applied to large and flexible systems such as riboswitches...

Biophysics

  • 2018 - 2022
    • •
  • 3 409 tis. Kč
    • •
  • 2 872 tis. Kč
    • •
  • GA ČR
Project

Structural studies of protein-RNA complexes involved in RNA quality control (GA204/08/1212)

To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings-the leftovers of RNA processing-but also improperly processed ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 6 990 tis. Kč
    • •
  • 2 490 tis. Kč
    • •
  • GA ČR
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