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509 (0,128s) •

Project

Mechanisms of increased ischaemic tolerance in chronically hypoxic heart (GA305/01/0279)

Hearts of animals subjected to chronic hypoxia exhibit increased tolerance to acute ischaemic insult but the precise mechanism remains largely unresolved. The proposed project will. therefore, attempt to disclose how the long-term adaptation...

ED - Fyziologie

  • 2001 - 2003
    • •
  • 5 991 tis. Kč
    • •
  • 2 375 tis. Kč
    • •
  • GA ČR
Project

Role of oxidative stress in ischemic tolerance of normoxic and chronically hypoxic myocardium (GP305/06/P372)

Adaptation to chronic hypoxia affords increased ischemic tolerance to acute oxygen deprivation but the underlying mechanism remains obscure. The objective willbe examinated. Susceptibility of chronically hypoxic and control normoxic...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2006 - 2008
    • •
  • 779 tis. Kč
    • •
  • 779 tis. Kč
    • •
  • GA ČR
Project

Optimisation of artificial reproduction in sterlet for the purpose of repatriation and conservation of genetic resources (QL24010011)

. Next goal is to assess low oxygen tolerance and reproductive potential of abnormal...

Reproductive biology (medical aspects to be 3)

  • 2024 - 2028
    • •
  • 12 946 tis. Kč
    • •
  • 10 947 tis. Kč
    • •
  • MZe
Project

FMISO-based protocol for adaptive radiotherapy in head and neck cancer (NU22-03-00435)

that the escalation of dose to hypoxic tumors improves outcomes. These considerations lead to hypothesis that personalized dose escalation by 10-15% to the hypoxic tumors may be safe as the predictive value of dynamic changes in

Oncology

  • 2022 - 2025
    • •
  • 9 858 tis. Kč
    • •
  • 9 858 tis. Kč
    • •
  • MZ
Project

Anoxic tolerance and Ca2+ homeostasis of right and left ventricular myocytes isolated from chronically hypoxic hearts (IAA500110804)

tolerance of IH hearts. Viability of right and left ventricular myocytes subjected...

ED - Fyziologie

  • 2008 - 2010
    • •
  • 1 512 tis. Kč
    • •
  • 1 512 tis. Kč
    • •
  • AV ČR
Project

Hypoxic fetoplacental vasoconstriction (NE4538)

Hypoxic fetoplacental vasoconstriction is considered one of the important causes of the low birth weight.However,it has never been conclusively demonstrated.The aim of this study is to prove its existence and physiolog. and pathophysiolog.l ...

FG - Pediatrie

  • 1998 - 2000
    • •
  • 1 754 tis. Kč
    • •
  • 1 754 tis. Kč
    • •
  • MZ
Project

Polymer-based supramolecular radiosensitizers for anticancer radiotherapy (NW24-03-00387)

results in hypoxic cells formation. Treatment of hypoxic tumors is complicated due radiosensitizers to overcome the problem of low hypoxic tumor radiosensitivity. The proposed approach is based on restoration of radiosensi...

Pharmacology and pharmacy

  • 2024 - 2027
    • •
  • 13 562 tis. Kč
    • •
  • 13 562 tis. Kč
    • •
  • MZ
Project

Anterior eye segment hypoxia and post-hypoxic injury. The role of oxidative stress. Attempts at the development of effective therapies. (GA304/06/1379)

Anterior eye segment hypoxia and post-hypoxic injury after reoxygenation is dangerous to the eye from the development of severe ocular lesions leading oxygen uptake (hypoxic hypoxia), impaired oxygen consumption (histotoxic hypoxia ...

FF - ORL, oftalmologie, stomatologie

  • 2006 - 2008
    • •
  • 4 991 tis. Kč
    • •
  • 4 991 tis. Kč
    • •
  • GA ČR
Project

Role of mitochondria in cell hypoxic adaptation (LH11055)

. To investigate the role of intermebrane space in hypoxic adaptations (ALR, an augmenter of mitochondria upon hypoxic adaptation. The University of Colorado outstanding models of hypoxic chambers for obtaining model primar...

ED - Fyziologie

  • 2011 - 2014
    • •
  • 2 960 tis. Kč
    • •
  • 2 960 tis. Kč
    • •
  • MŠMT
Project

Aging of the eye The role of oxidative, mechanical and hypoxic stress. Pramature aging of the eye and new approaches of prevention (NG16)

The rle of oxidative,hypoxic and mechanical stress on aging of the eye.Pramature aging of the eye and new approaches of its prevention by means of antioxidant agents and newly developed contact lenses producing minimal hypoxic and m...

FF - ORL, oftalmologie, stomatologie

  • 1998 - 2000
    • •
  • 3 500 tis. Kč
    • •
  • 2 868 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 509