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10 348 (0,16s) •

Project

Cytochrome P450 active sites (OC 133)

study of compresibility and flexibility of active sites of P450 cytocromes, forms CYP2C9 and CYP3A4...

CE - Biochemie

  • 2006 - 2007
    • •
  • 1 180 tis. Kč
    • •
  • 800 tis. Kč
    • •
  • MŠMT
Project

Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450 (GPP303/12/P019)

The microsomal cytochromes P450 (CYPs) are enzymes capable of metabolizing foreign substances (xenobiotics) such as drugs or pollutants during the first-pass metabolism in liver. The structure of the CYP enzyme contains buried a...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2014
    • •
  • 976 tis. Kč
    • •
  • 976 tis. Kč
    • •
  • GA ČR
Project

Role of Cytochromes P450 in the Effects of Cytostatics in Patients and Medical Personnel. (IZ1850)

Cytochromes P450 activate many carcinogens and anticancer to effective metabolites. Genetic and environmental factors influence P 450 activuty. The proposal studies relation of P450 activity to the effects...

FM - Hygiena

  • 1995 - 1999
    • •
  • 4 852 tis. Kč
    • •
  • 3 817 tis. Kč
    • •
  • MZ
Project

Expression of cytochromes P450 in hematopoietic stem cells. (NL7295)

Expression of cytochromes P450 in hematopoietic stem cells obtained by separetion from petipheral blood will be follewed by Northern blogging, real-time PCR, Western blotting and by determination of specific enzyme activities

FR - Farmakologie a lékárnická chemie

  • 2002 - 2004
    • •
  • 1 528 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • MZ
Project

Structure and function of cytochromes P450 of human and (mini)pig origin (GA203/02/1152)

and function) of three cytochromes P450 of human and minipig origin. CYP3A, CYP2A and CYP2E. Theproperties of their active site will be examined and compared to their supposed of the project is determined by the f...

CE - Biochemie

  • 2002 - 2004
    • •
  • 2 087 tis. Kč
    • •
  • 1 350 tis. Kč
    • •
  • GA ČR
Project

Study of the possible increase of poultry productivity by modulation of cytochrome P450 expression and activity during chicken embryonic and postemb (GA523/01/0840)

The aim of the grant proposal is to prove that the modulation of expression and activity of CYP19, cytochrome P450 involved in biosynthesis of estrogenic steroid hormones, is able to gently tune the hormonal status of a mod...

GG - Chov hospodářských zvířat

  • 2001 - 2003
    • •
  • 4 149 tis. Kč
    • •
  • 4 035 tis. Kč
    • •
  • GA ČR
Project

Structural Determinants of Substrate Specificity of Human Cytochromes P450 (GA303/09/1001)

important Cytochromes P450 (CYPs) taking part in the metabolism of drugs. The individual) and CYP2A6 (for comparison ? as the enzyme with small active site metabolizing only of preclinically screened active

CE - Biochemie

  • 2009 - 2012
    • •
  • 2 981 tis. Kč
    • •
  • 2 981 tis. Kč
    • •
  • GA ČR
Project

Porcine enzymes of biotransformation (OC09003)

The aim of the project is to compare the properties of the main enzymes of biotransformation of foreign compounds in pig and in the man, namely, cytochromes P450 and uridindiphosphoglucuronosyltransferases (UGT). Activities...

CE - Biochemie

  • 2009 - 2009
    • •
  • 500 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MŠMT
Project

Role of cytochrome P450 in biodegradation of dyes and triazines by white rot fungi (1P05ME827)

mechanism of degradation of xenobiotics focused on systems containing p450 cytochrom, used by white rot fungi...

EE - Mikrobiologie, virologie

  • 2005 - 2005
    • •
  • 205 tis. Kč
    • •
  • 87 tis. Kč
    • •
  • MŠMT
Project

Expression of Human Cytochrome P450 2A6 in Bacteria (IZ3505)

FM - Hygiena

  • 1996 - 1998
    • •
  • 2 097 tis. Kč
    • •
  • 2 097 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 10 348