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3 300 (0,147s) •

Project

Small binding proteins targeting PD-1/PD-L1 immune checkpoint proteins as new diagnostic tools (NU21-03-00372)

goal of the proposal is to develop a unique set of high-affinity binding small cancer cell membrane ligand-1 (PD-L1) ensuring negative regulation of the immune by selection from combinatorial libraries derived from scaffol...

Oncology

  • 2021 - 2024
    • •
  • 12 979 tis. Kč
    • •
  • 12 979 tis. Kč
    • •
  • MZ
Project

Theoretical investigation of RNA structure, dynamics and function and their relationship. (ME09019)

(1) Finding new information about structure, dynamics and function of small RNA Yarus and bioinformatist Rob Knight). (2) Characterization of binding sites (example of free and bound form of riboswitches and the conformational chang...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 1 660 tis. Kč
    • •
  • 1 660 tis. Kč
    • •
  • MŠMT
Project

Interaction of bacterial sensor kinase with peptidoglycan subunits and its impact on the cell wall biosynthesis (LH12055)

of its binding with the synthetic ligands. Furthermore, we anticipate to use site the binding site for the ligands will result in sensor domain with diminished affinity or abrogated binding ability for th...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 3 244 tis. Kč
    • •
  • 3 152 tis. Kč
    • •
  • MŠMT
Project

Allosteric regulation of muscarinic acetylcholine receptors (GA309/99/0214)

:(a) To develop a radiolabelled ligand specifically binding to the allosteric binding sites, and to utilize it for the elucidation of the binding properties of these sites, for the search of endogenous ligands<...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 4 833 tis. Kč
    • •
  • 4 146 tis. Kč
    • •
  • GA ČR
Project

Macromolecular conjugates for targeted drug delivery, imaging and isolation of proteins based on hydrophilic polymers decorated by functional moieties (GA16-02938S)

that will use synthetic small molecule ligand of a biomolecule as the “homing device (PSMA), carbonic anhydrase IX or viral neuraminidase), evaluate their binding biocompatible polymers. We shall then analyze the bindi...

CE - Biochemie

  • 2016 - 2019
    • •
  • 10 914 tis. Kč
    • •
  • 9 439 tis. Kč
    • •
  • GA ČR
Project

The structure and function of the nicotinic acetylcholine receptor (IAA7011902)

We will use a combination of site-directed mutagenesis and patch clamp to investigate the binding of ligands to the nAChR and the coupling terween ligand binding each of the ligand binding sites. ...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 5 144 tis. Kč
    • •
  • 2 339 tis. Kč
    • •
  • AV ČR
Project

8-Substituted Analogues of Cytokinins - Utilization of their Potential New Quality in Plant Research (KJB6137301)

8-Substituted analogues of natural cytokinins with small substituents in position 8 will be prepared and their structure-activity reationship compared in three or to fluorescentprobes. The first group of protein conjugates will werve as ...

EF - Botanika

  • 2003 - 2005
    • •
  • 3 653 tis. Kč
    • •
  • 978 tis. Kč
    • •
  • AV ČR
Project

The use of affinity chromatography for identification of sterol-binding proteins from plants (IAA4055204)

questions about the mode of steroid-binding and transport in higher plants. The genome-binding proteins (OBPs) that play a pivotal role int the regulation of cholesterol pathways as ligands, bound by the side-chain of the ...

CC - Organická chemie

  • 2002 - 2006
    • •
  • 4 941 tis. Kč
    • •
  • 2 661 tis. Kč
    • •
  • AV ČR
Project

Polymer supports cintaining immobilized metal ions for protein purification (IAA4050910)

modified with various chelating ligands and coordinated with transition or hard Lewis membranes for a study of a correlation between the accessibility of chelating ligands to protein binding and their sorption selectivity ...

CD - Makromolekulární chemie

  • 1999 - 2001
    • •
  • 3 601 tis. Kč
    • •
  • 1 054 tis. Kč
    • •
  • AV ČR
Project

Interactions of platinum metal complexes containing substituted 6-benzylaminopurines as ligands with DNA and microsomal cytochromes P450 (GPP208/10/P466)

that platinum drugs which bind to DNA in a fundamentally different manner as non-leaving ligands has been prepared. Considering character of these complexes the DNA binding activity is expected. In addition, binding

BO - Biofyzika

  • 2010 - 2014
    • •
  • 1 462 tis. Kč
    • •
  • 1 462 tis. Kč
    • •
  • GA ČR
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