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1 452 (0,093s) •

Project

How lipid asymmetry influences membrane protein function (GF25-19982L)

, elucidating the structural and dynamical properties of lipids in asymmetric membranes and their interactions with integral membrane proteins, focusing on bacterial lipid compositions. WeDespite the inherent asymm...

Biophysics

  • 2025 - 2027
    • •
  • 5 318 tis. Kč
    • •
  • 5 318 tis. Kč
    • •
  • GA ČR
Project

Deciphering the molecular mechanism of lipid-induced topological switching of membrane proteins (LUAUS25113)

to the changes of its lipid environment. It is widely accepted that membrane proteins always in the membrane in response to changes in the lipid environment or charge, membrane insertion and functioning ...

Biophysics

  • 2025 - 2028
    • •
  • 4 924 tis. Kč
    • •
  • 4 924 tis. Kč
    • •
  • MŠMT
Project

Structural and functional analysis of regulation of the lipid-transport protein ORP8 (GF21-27735K)

Lipids transport between various membranous intracellular organelles proteins (ORPs) mediate lipid transfer at the membrane contact sites such as the ER-plasma membrane (PM) contact site. This ensures ...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 4 220 tis. Kč
    • •
  • 3 260 tis. Kč
    • •
  • GA ČR
Project

Peptide Killers of Bacteria (LL2007)

We will develop a method for the targeting of peptides to membranes with specific lipid composition and determine key peptide properties for membrane translocation and pore formation. The designed peptides will be experimen...

Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

  • 2020 - 2021
    • •
  • 13 476 tis. Kč
    • •
  • 13 476 tis. Kč
    • •
  • MŠMT
Project

Concert of lipids, ions, and proteins in cell membrane dynamics and function (GX19-26854X)

the interplay between membranes with complex lipid compositions and topologies together, and lipid membranes regulates signalling proteins, and iii) determine mechanismsIn a traditional view of cellular processes ...

Biophysics

  • 2019 - 2024
    • •
  • 60 475 tis. Kč
    • •
  • 49 471 tis. Kč
    • •
  • GA ČR
Project

Roles of non-bilayer lipids and non-lamellar lipid phases in the structure, dynamics and function of plant thylakoid membranes (GA19-13637S)

The proposal deals with one of the enigmatic questions of membrane biology, the role of non-bilayer membrane lipids - focusing on plant thylakoid membranes, an exemplary of energy-converting membranes. The...

Plant sciences, botany

  • 2019 - 2022
    • •
  • 11 472 tis. Kč
    • •
  • 11 325 tis. Kč
    • •
  • GA ČR
Project

Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (GA13-23891S)

membrane models of the lipid skin barrier in atopic dermatitis and other skin diseases to gain a detailed insight into the role of lipid abnormalities in these diseases such as membrane thickness and fluidity,

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 734 tis. Kč
    • •
  • 9 734 tis. Kč
    • •
  • GA ČR
Project

Bottom-up unraveling of biophysical determinants of ORP5/8 mediated lipid transport using in vitro reconstitution and model membranes (GA19-18917S)

Membrane homeostasis requires organized transport of lipids from the endoplasmic reticulum (ER) to target membrane. Oxysterol binding protein related proteins (ORPs) represent a family of lipid transfer proteins, t...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 3 705 tis. Kč
    • •
  • 3 705 tis. Kč
    • •
  • GA ČR
Project

The plasticity of protein-lipid interfaces in plant membranes perceived through evolutionary lenses (GA22-35916S)

about the crosstalk and evolutionary dynamics between membrane lipids and peripheral membrane proteins. We aim to investigate the evolution of plasma membrane-protein proteins and their interaction with plasma

Cell biology

  • 2022 - 2024
    • •
  • 6 688 tis. Kč
    • •
  • 6 688 tis. Kč
    • •
  • GA ČR
Project

Role of membrane potential in the lateral microdomain organization of the plasma membrane (GAP205/12/0720)

Depending on their actual chemical composition, membranes are subdivided into dynamic microdomains differing in size, lipid order and physical properties. Rearrangement of the microdomains strongly modulates biochemical processes on...

BO - Biofyzika

  • 2012 - 2014
    • •
  • 6 230 tis. Kč
    • •
  • 6 230 tis. Kč
    • •
  • GA ČR
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