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2 066 (0,129s) •

Project

Mitochondrial DNA in tumors and metabolic syndrome (GPP305/12/P388)

Mitochondrial dysfunction associated with metabolic syndrome and carcinogenesis is characterized by depletion in mitochondrial DNA (mt DNA) content and related decrease for development of mt DNA centered t...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 2 460 tis. Kč
    • •
  • 2 460 tis. Kč
    • •
  • GA ČR
Project

Precision Control of Mitochondrial DNA via Structure–Sequence Integration for Medical Applications (LUAKR25078)

, within mitochondrial DNA (mtDNA). This includes understanding their roles for the visualization of mitochondria and mitochondrial DNA structures. This will provide insights the understanding of how local DNA<...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 4 869 tis. Kč
    • •
  • 4 869 tis. Kč
    • •
  • MŠMT
Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

and mortality. OXPHOS biogenesis is under dual genetic control, mitochondrial DNA (mtDNA will elucidate genetic bases of mitochondrial DNA instability in 55 patients, to identifyMitochondrial disorders (M...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

The mitochondrial genome and oxidative phosphorylation system in metabolic syndrome (OC08017)

strains with identical nuclear genome but different haplotypes of mitochondrial DNAMitochondrial oxidative phosphorylation (OXPHOS) provides most of energy and mitochondrial genes. Dysfunction of OXPHOS are known ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 1 706 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • MŠMT
Project

Mitochondrial DNA manipulations for simulation of oxidative stress (KJB500110902)

The project will i) develop methods for nucleic acid import into the mitochondrial matrix of living cells such as HEPG2, HeLa, or INS1E cells, (using DNA-polyethylenimine conjugates with the mitochondrial addressing peptide...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 1 797 tis. Kč
    • •
  • 1 797 tis. Kč
    • •
  • AV ČR
Project

Imaging of mitochondrial substructure by 3D high resolution microscopy (ME09029)

imaging of mitochondrial network morphology in cells and 3D imaging of superposition of mitochondrial nucleoids (clusters of mtDNA) will be achieved. Fluorescent protein (FP membrane marker proteins. Mitochondrial nucleoid...

EA - Morfologické obory a cytologie

  • 2009 - 2012
    • •
  • 2 376 tis. Kč
    • •
  • 2 376 tis. Kč
    • •
  • MŠMT
Project

Modulation of mitochondrial functions in cancer cells by the mitochondrially targeted vitamin E analogues (GAP305/12/1708)

the complexII of the mitochondrial respiratory chain and production of oxidativestress. Our preliminary data suggest that mitochondrially targeted vitamin E analogues (MitoVES) significantly affect mitochondrial transcript...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 944 tis. Kč
    • •
  • 4 944 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial dysfunctions in bipolar affective disorder (NV15-28616A)

) will be measured in peripheral blood components. Furthermore, changes in mitochondrial DNA and questionnaires; selected mitochondrial parameters (citrate synthase and electron transport chain complexes activities, ATP pro...

FL - Psychiatrie, sexuologie

  • 2015 - 2018
    • •
  • 7 502 tis. Kč
    • •
  • 7 502 tis. Kč
    • •
  • MZ
Project

Genetics and functional manifestation of heteroplasmic mt DNA mutations (GA302/99/0648)

Only very few mitochondrial diseases caused by mitochondrial DNA (mtDNA. Genetics and transmission of mt DNA heteroplasmic mutations, their expression further developsprevious research of the applicants on mito...

FP - Ostatní lékařské obory

  • 1999 - 2001
    • •
  • 4 588 tis. Kč
    • •
  • 4 333 tis. Kč
    • •
  • GA ČR
Project

Genetic causes of mitochondrial diseases due to deficiency of ATP synthase (NS9759)

Identification of nuclear genetic determinants of inborn isolated defects of mitochondrial ATPase using methods of molecular genetics and cell biology and unique collection of genomic DNA, fibroblast cell lines and tissue samples fr...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 9 899 tis. Kč
    • •
  • 9 899 tis. Kč
    • •
  • MZ
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