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890 (0,149s) •

Project

The miRNA expression diversity study in chronic myelogeneous leukemia (GP301/08/P154)

Chronic myelogeneous leukemia (CML) is a malignant disorder caused by abnormal function of fusion protein BCR-ABL as the consequence of reciprocal translocation t(9;22) (q34;q11). A great progress in CML treatment was achie...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 993 tis. Kč
    • •
  • 993 tis. Kč
    • •
  • GA ČR
Project

Detection of de novo methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. (IZ3720)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 684 tis. Kč
    • •
  • 684 tis. Kč
    • •
  • MZ
Project

Bone marrow transplantation in the therapy of chronic myelogenous leukemia (IZ1915)

9F - 9

  • 1994 - 1996
    • •
  • 2 000 tis. Kč
    • •
  • 3 100 tis. Kč
    • •
  • MZ
Project

Analysis of the proteome of malignant cells two-dimensional elektrophoresis and mass spectrometry (GA303/01/1445)

Studies of the global protein expression (the proteome) of leukemia cell lines derived from several types of leukemia HL60 (promyelocytic leukemia), HEL (erythroleukemia), K562 (chronic myelogenous leu...

CE - Biochemie

  • 2001 - 2003
    • •
  • 4 204 tis. Kč
    • •
  • 2 925 tis. Kč
    • •
  • GA ČR
Project

Study of the disturbancies of cell adhesion regulation in hematological malignancies (NR9243)

The adhesive properties of leukemia cells and cell lines derived from chronic myelogenous leukemia (CML) K562, JURL-MK1, to the extracellular matrix compounds (fibronectin, collagen, laminin, vitronectin) will be s...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 11 114 tis. Kč
    • •
  • 10 535 tis. Kč
    • •
  • MZ
Project

Pathophyziologie of Chronic Myelogenous Leukemia - Cellular and Mouse Model of the Disease (NC6652)

Cellular lmodel of ligand-inducible and constitutively active abl PTK created by knock-in to our already developed EPOR-tagged ES cells, in vitro differentiation of these cell lines. Role of growth factors in leukemogenesis of CML. Mouse model of con...

FD - Onkologie a hematologie

  • 2001 - 2004
    • •
  • 3 692 tis. Kč
    • •
  • 3 592 tis. Kč
    • •
  • MZ
Project

Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach (NL7681)

The molecular mechanisms of therapeutic effects of cytokine Interferon - alfa, signal transduction inhibitor STI571, proteasome inhibitor and photodynamic therapy will be studied at the protein level. By proteome analysis methods (two-dimensional gel...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 9 659 tis. Kč
    • •
  • 9 374 tis. Kč
    • •
  • MZ
Project

Mechanisms of imatinib resistance in patients with chronic myelogenous leukaemia (NR7870)

In patients with Ph+ CML the residual, in vitro-IM-resistant subclones are tested for qualitative changes (using sequencing of BCR/ABL ATP-binding pocket) and for quantitative gene changes using DNA (CGH microarray) technology.......

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 370 tis. Kč
    • •
  • 3 187 tis. Kč
    • •
  • MZ
Project

Methylation changes in regulatory regions of DNA as an universal marker of acute myelogenous leukemia. (IZ1921)

FD - Onkologie a hematologie

  • 1994 - 1997
    • •
  • 4 635 tis. Kč
    • •
  • 5 074 tis. Kč
    • •
  • MZ
Project

Utilization of centrosomal proteins for prognostication and vaccinotherapy of chronic myeloid leukemia (NT13862)

Search for prognostic markers of chronic myelogenous leukemia (CML) and development of DNA vaccines against this disease based on increased production of centrosomal proteins. Detection of HMMR/RHAMM, AURKA and ESPL1 mRNA l...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 9 681 tis. Kč
    • •
  • 9 681 tis. Kč
    • •
  • MZ
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